Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

M. S. Brown, R. G W Anderson, J. L. Goldstein

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Studies comparing the metabolism of low density lipoprotein (LDL) in normal cells and in cells cultured from patients with homozygous familial hypercholesterolemia have disclosed the existence of a receptor for plasma LDL. This receptor has been identified on the surface of human fibroblasts, lymphocytes, and aortic smooth muscle cells. An extension of these studies to cell strains derived from patients with other single gene defects in cholesterol metabolism has provided additional insight into the normal mechanisms by which cells regulate their cholesterol content and how alterations in these genetic control mechanisms may predispose to atherosclerosis in man.

Original languageEnglish (US)
Title of host publicationJournal of Supramolecular and Cellular Biochemistry
Pages85-94
Number of pages10
Volume6
Edition1
StatePublished - 1977

Fingerprint

Lymphocytes
Fibroblasts
LDL Lipoproteins
Metabolism
Smooth Muscle Myocytes
Muscle
Hydrolysis
Cholesterol
Cells
Mutation
Inborn Genetic Diseases
Hyperlipoproteinemia Type II
Genes
LDL Receptors
Plasmas
Defects
Cultured Cells
Atherosclerosis

ASJC Scopus subject areas

  • Biochemistry

Cite this

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells. / Brown, M. S.; Anderson, R. G W; Goldstein, J. L.

Journal of Supramolecular and Cellular Biochemistry. Vol. 6 1. ed. 1977. p. 85-94.

Research output: Chapter in Book/Report/Conference proceedingChapter

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