250 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) gene product is a receptor tyrosine kinase (TK) that affects many important downstream pathways. The recent finding that mutations in EGFR predict the response of lung cancers to therapies that target the TK domain of the gene product has generated considerable interest. The mutations are associated with adenocarcinoma histology, oriental origin, female gender and never-smoker status. Most mutations target structures in the TK domain that appear to be essential for the phosphorylation function of the gene. Cancer cells with mutant EGFR genes might become physiologically dependent on the continued activity of the gene for the maintenance of their malignant phenotype; however, this might also be a target for therapy.

Original languageEnglish (US)
Pages (from-to)481-486
Number of pages6
JournalTrends in Molecular Medicine
Volume10
Issue number10
DOIs
StatePublished - Oct 2004

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Epidermal Growth Factor Receptor
erbB-1 Genes
Lung Neoplasms
Protein-Tyrosine Kinases
Mutation
Genes
Receptor Protein-Tyrosine Kinases
Histology
Adenocarcinoma
Maintenance
Phosphorylation
Phenotype
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mutations and addiction to EGFR : The Achilles 'heal' of lung cancers? / Gazdar, Adi F.; Shigematsu, Hisayuki; Herz, Joachim; Minna, John D.

In: Trends in Molecular Medicine, Vol. 10, No. 10, 10.2004, p. 481-486.

Research output: Contribution to journalArticle

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