@article{d4a9a0cecc004b3793ee4789bc8b4082,
title = "Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components",
abstract = "The exocyst is a complex of proteins originally identified in yeast that has been implicated in polarized secretion. Components of the exocyst have been implicated in neurite outgrowth, cell polarity, and cell viability. We have isolated an exocyst component, sec15, in a screen for genes required for synaptic specificity. Loss of sec15 causes a targeting defect of photoreceptors that coincides with mislocalization of specific cell adhesion and signaling molecules. Additionally, sec15 mutant neurons fail to localize other exocyst members like Sec5 and Sec8, but not Sec6, to neuronal terminals. However, loss of sec15 does not cause cell lethality in contrast to loss of sec5 or sec6. Our data suggest a role of Sec15 in an exocyst-like subcomplex for the targeting and subcellular distribution of specific proteins. The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions.",
author = "Mehta, {Sunil Q.} and Hiesinger, {P. Robin} and Slobodan Beronja and Zhai, {R. Grace} and Schulze, {Karen L.} and Patrik Verstreken and Yu Cao and Yi Zhou and Ulrich Tepass and Crair, {Michael C.} and Bellen, {Hugo J.}",
note = "Funding Information: We would like to thank S. Carroll, K. Cho, A. Hofbauer, G. Mardon, T.L. Schwarz, T. Uemura, D. Van Vactor, A. Wodarz, S. Wu, S.L. Zipursky, the Bloomington Stock Center, and the University of Iowa Developmental Studies Hybridoma Bank for reagents. We especially thank Iris Salecker for making the ey3.5FLP system available to us prior to publication. We would also like to thank H. Andrews, M. Acar, and H. Jafar-Nejad for critical reading of the manuscript and Bellen lab members for comments and discussion. S.Q.M. is supported by NIH grants EY07001 and MH62639 and is a member of the Medical Scientist Training Program. P.R.H., R.G.Z., K.L.S., and H.J.B. are supported by the HHMI. P.R.H. was further supported by an EMBO long-term fellowship. S.B. is supported by a Vision Science Research Program fellowship. This work was also supported by NIH grant MH62639 (to M.C.C.). H.J.B. is an HHMI Investigator. ",
year = "2005",
month = apr,
day = "21",
doi = "10.1016/j.neuron.2005.02.029",
language = "English (US)",
volume = "46",
pages = "219--232",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}