Mutual regulation between the spindle checkpoint and APC/C

Soonjoung Kim, Hongtao Yu

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Accurate chromosome segregation during mitosis is critical for maintaining genomic stability. The spindle checkpoint is a cellular surveillance system that ensures the fidelity of chromosome segregation. In response to sister chromatids not properly captured by spindle microtubules, the spindle checkpoint interferes with the functions of Cdc20, the mitotic activator of the anaphase-promoting complex or cyclosome (APC/C), thereby blocking APC/C-mediated degradation of securin and cyclin B to delay anaphase onset. This review summarizes the recent progress on the mechanisms by which checkpoint proteins inhibit APC/C, the conformational and enzymatic activation of checkpoint proteins, and the emerging roles of APC/C-dependent ubiquitination in checkpoint inactivation.

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume22
Issue number6
DOIs
StatePublished - Aug 2011

Keywords

  • Cell cycle
  • Chromosome segregation
  • Mitosis
  • Ubiquitination

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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