Abstract
Accurate chromosome segregation during mitosis is critical for maintaining genomic stability. The spindle checkpoint is a cellular surveillance system that ensures the fidelity of chromosome segregation. In response to sister chromatids not properly captured by spindle microtubules, the spindle checkpoint interferes with the functions of Cdc20, the mitotic activator of the anaphase-promoting complex or cyclosome (APC/C), thereby blocking APC/C-mediated degradation of securin and cyclin B to delay anaphase onset. This review summarizes the recent progress on the mechanisms by which checkpoint proteins inhibit APC/C, the conformational and enzymatic activation of checkpoint proteins, and the emerging roles of APC/C-dependent ubiquitination in checkpoint inactivation.
Original language | English (US) |
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Pages (from-to) | 551-558 |
Number of pages | 8 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 22 |
Issue number | 6 |
DOIs | |
State | Published - Aug 2011 |
Keywords
- Cell cycle
- Chromosome segregation
- Mitosis
- Ubiquitination
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology