Myasthenia gravis, thymoma, and intestinal pseudo-obstruction

Goran Rakocevic, Richard Barohn, April L. McVey, Ivan Damjanov, Paul D. Morte, Steven Vernino, Vanda Lennon

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We report a 28-year-old man who presented with intestinal pseudo-obstruction as the initial manifestation of thymoma, myasthenia gravis, and dysautonomia. The patient's autoantibody profile was characteristic of this constellation of disorders, being positive for both muscle and ganglionic nicotinic acetylcholine receptor antibodies and striational antibody. Inflammatory cell infiltrates were found in the myenteric plexus of the stomach and small intestine. Review of 12 previously reported cases suggests that patients with both myasthenia gravis and dysautonomia in the context of thymoma respond poorly to therapy.

Original languageEnglish (US)
Pages (from-to)93-95
Number of pages3
JournalJournal of Clinical Neuromuscular Disease
Volume5
Issue number2
DOIs
StatePublished - Dec 1 2003

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Keywords

  • Intestinal pseudo-obstruction
  • Myasthenia gravis
  • Nicotinic ganglionic acetylcholine receptor antibodies
  • Thymoma

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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