myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines

B. E. Johnson, R. W. Makuch, A. D. Simmons, A. F. Gazdar, D. Burch, A. W. Cashell

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Abstract

Tumor specimens procured from 38 different small cell lung cancer patients were studied for DNA amplification of the myc family of protooncogenes (c-myc, N-myc, and L-myc). Six of the 38 specimens (16%) had 4-fold or greater myc family DNA amplification (N-myc in 4 and L-myc in 2). All 6 tumors with amplification came from patients who had received combination chemotherapy. The myc family gene copy number of the DNA prepared from 9 tumor cell lines established from these 38 patients was similar to the myc family gene copy number in the DNA prepared from fresh tumor specimens from these same patients. myc family DNA amplification is present in 16% of small cell lung cancer patients' tumors and the amplification pattern in the tumor cell lines is representative of the fresh tumors obtained from the same patients.

Original languageEnglish (US)
Pages (from-to)5163-5166
Number of pages4
JournalCancer Research
Volume48
Issue number18
StatePublished - 1988

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Small Cell Lung Carcinoma
Tumor Cell Line
DNA
myc Genes
Gene Dosage
Neoplasms
Combination Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Johnson, B. E., Makuch, R. W., Simmons, A. D., Gazdar, A. F., Burch, D., & Cashell, A. W. (1988). myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. Cancer Research, 48(18), 5163-5166.

myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. / Johnson, B. E.; Makuch, R. W.; Simmons, A. D.; Gazdar, A. F.; Burch, D.; Cashell, A. W.

In: Cancer Research, Vol. 48, No. 18, 1988, p. 5163-5166.

Research output: Contribution to journalArticle

Johnson, BE, Makuch, RW, Simmons, AD, Gazdar, AF, Burch, D & Cashell, AW 1988, 'myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines', Cancer Research, vol. 48, no. 18, pp. 5163-5166.
Johnson BE, Makuch RW, Simmons AD, Gazdar AF, Burch D, Cashell AW. myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. Cancer Research. 1988;48(18):5163-5166.
Johnson, B. E. ; Makuch, R. W. ; Simmons, A. D. ; Gazdar, A. F. ; Burch, D. ; Cashell, A. W. / myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. In: Cancer Research. 1988 ; Vol. 48, No. 18. pp. 5163-5166.
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