MYC leads the way

Niranjan Venkateswaran, Maralice Conacci-Sorrell

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Members of the MYC family of proto-oncogenes are the most commonly deregulated genes in all human cancers. MYC proteins drive an increase in cellular proliferation and facilitate multiple aspects of tumor initiation and progression, thereby controlling all hallmarks of cancer. MYC's ability to drive metabolic reprogramming of tumor cells leading to biomass accumulation and cellular proliferation is the most studied function of these oncogenes. MYC also regulates tumor progression and is often implicated in resistance to chemotherapy and in metastasis. While most oncogenic functions of MYC are attributed to its role as a transcription factor, more recently, new roles of MYC as a pro-survival factor in the cytoplasm suggest a previously unappreciated diversity in MYC's roles in cancer progression. This review will focus on the role of MYC in invasion and will discuss the canonical functions of MYC in Epithelial to Mesenchymal Transition and the cytoplasmic functions of MYC-nick in collective migration.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalSmall GTPases
Volume11
Issue number2
DOIs
StatePublished - Mar 3 2020

Keywords

  • EMT
  • metastasis
  • migration
  • MYC
  • MYC-nick

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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