Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice

Monica Fonseca-Aten, Ana M. Ríos, Asunción Mejías, Susana Chávez-Bueno, Kathy Katz, Ana M. Gómez, George H. McCracken, R. Doug Hardy

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Respiratory tract infections result in wheezing in a subset of patients. Mycoplasma pneumoniae is a common etiologic agent of acute respiratory infection in children and adults that has been associated with wheezing in 20-40% of individuals. The current study was undertaken to elucidate the host-dependent pulmonary and immunologic response to M. pneumoniae respiratory infection by studying mice with different immunogenetic backgrounds (BALB/c mice versus C57BL/6 mice). After M. pneumoniae infection, only BALB/c mice developed significant airway obstruction (AO) compared with controls. M. pneumoniae-infected BALB/c mice manifested significantly elevated airway hyperresponsiveness (AHR) compared with C57BL/6 mice 4 and 7 d after inoculation as well as BALB/c control mice. Compared with C57BL/6 mice, BALB/c mice developed worse pulmonary inflammation, including greater peribronchial infiltrates. Infected BALB/c mice had significantly higher concentrations of tumor necrosis factor-α, interferon-γ, interleukin (IL)-1β, IL-6, IL-12, KC (functional IL-8), and macrophage inflammatory protein 1α in the bronchoalveolar lavage fluid compared with infected C57BL/6 mice. No differences in IL-2, IL-4, IL-5, IL-10, and granulocyte/macrophage colony-stimulating factor concentrations were found. The mice in this study exhibited host-dependent infection-related AO and AHR associated with chemokine and T-helper type (Th)1 pulmonary host response and not Th2 response after M. pneumoniae infection.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume32
Issue number3
DOIs
StatePublished - Mar 2005

Fingerprint

Mycoplasma pneumoniae
Airway Obstruction
Pneumonia
Inbred C57BL Mouse
Respiratory Tract Infections
Macrophage Inflammatory Proteins
Interleukin-5
Respiratory Sounds
Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-8
Interleukin-1
Chemokines
Interleukin-4
Interleukin-10
Interferons
Interleukin-2
Interleukin-6
Tumor Necrosis Factor-alpha
Infection

Keywords

  • Airway hyperresponsiveness
  • Airway obstruction
  • Asthma
  • Chemokines
  • Cytokines
  • Mycoplasma pneumoniae

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology

Cite this

Fonseca-Aten, M., Ríos, A. M., Mejías, A., Chávez-Bueno, S., Katz, K., Gómez, A. M., ... Hardy, R. D. (2005). Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. American Journal of Respiratory Cell and Molecular Biology, 32(3), 201-210. https://doi.org/10.1165/rcmb.2004-0197OC

Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. / Fonseca-Aten, Monica; Ríos, Ana M.; Mejías, Asunción; Chávez-Bueno, Susana; Katz, Kathy; Gómez, Ana M.; McCracken, George H.; Hardy, R. Doug.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 32, No. 3, 03.2005, p. 201-210.

Research output: Contribution to journalArticle

Fonseca-Aten, Monica ; Ríos, Ana M. ; Mejías, Asunción ; Chávez-Bueno, Susana ; Katz, Kathy ; Gómez, Ana M. ; McCracken, George H. ; Hardy, R. Doug. / Mycoplasma pneumoniae induces host-dependent pulmonary inflammation and airway obstruction in mice. In: American Journal of Respiratory Cell and Molecular Biology. 2005 ; Vol. 32, No. 3. pp. 201-210.
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