Myelin-reactive T cells and their regulation in multiple sclerosis

Although the cause of multiple sclerosis (MS) is unknown, advances in brain imaging, immunology and molecular biology have increased researchers' understanding of this disease. Several therapies are currently being used to treat MS, but no single therapy has demonstrated dramatic treatment efficacy, so the need for improved therapies remains. There is growing evidence that immune responses directed against myelin antigens plays a role in the pathogenesis of MS. Evidence also exists for the presence of immune cells which may regulate autoreactive cells present in both healthy individuals and MS patients. As knowledge in the area of T cell biology in MS grows, it is to be expected that useful and interpretable data will be obtained for the development of new, improved therapeutic regimens for MS. These results are eagerly anticipated.