Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex

Danielle Pham-Dinh, Marie Geneviève Mattei, Jean Louis Nussbaum, Guy Roussel, Pierre Pontarotti, Nathalie Roeckel, Ian H. Mather, Karen Artzt, Kirsten Fischer Lindahl, André Dautigny

Research output: Contribution to journalArticle

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Abstract

Myelin/oligodendrocyte glycoprotein (MOG) is found on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system, and it is a target antigen in experimental autoimmune encephalomyelitis and multiple sclerosis. We have isolated bovine, mouse, and rat MOG cDNA clones and shown that the developmental pattern of MOG expression in the rat central nervous system coincides with the late stages of myelination. The amino-terminal, extracellular domain of MOG has characteristics of an immunoglobulin variable domain and is 46% and 41% identical with the amino terminus of bovine butyrophilin (expressed in the lactating mammary gland) and B-G antigens of the chicken major histocompatibility complex (MHC), respectively; these proteins thus form a subset of the immunoglobulin superfamily. The homology between MOG and B-G extends beyond their structure and genetic mapping to their ability to induce strong antibody responses and has implications for the role of MOG in pathological, autoimmune conditions. We colocalized the MOG and BT genes to the human MHC on chromosome 6p21.3-p22. The mouse MOG gene was mapped to the homologous band C of chromosome 17, within the M region of the mouse MHC.

Original languageEnglish (US)
Pages (from-to)7990-7994
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number17
StatePublished - Sep 1 1993

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Myelin-Oligodendrocyte Glycoprotein
Major Histocompatibility Complex
Immunoglobulins
Central Nervous System
Antigens
Chromosomes, Human, Pair 17
Autoimmune Experimental Encephalomyelitis
Genetic Structures
Oligodendroglia
Human Mammary Glands
Myelin Sheath
Genes
Multiple Sclerosis
Antibody Formation
Chickens
Complementary DNA
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • General
  • Genetics

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Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. / Pham-Dinh, Danielle; Mattei, Marie Geneviève; Nussbaum, Jean Louis; Roussel, Guy; Pontarotti, Pierre; Roeckel, Nathalie; Mather, Ian H.; Artzt, Karen; Lindahl, Kirsten Fischer; Dautigny, André.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 17, 01.09.1993, p. 7990-7994.

Research output: Contribution to journalArticle

Pham-Dinh, D, Mattei, MG, Nussbaum, JL, Roussel, G, Pontarotti, P, Roeckel, N, Mather, IH, Artzt, K, Lindahl, KF & Dautigny, A 1993, 'Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex', Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 17, pp. 7990-7994.
Pham-Dinh, Danielle ; Mattei, Marie Geneviève ; Nussbaum, Jean Louis ; Roussel, Guy ; Pontarotti, Pierre ; Roeckel, Nathalie ; Mather, Ian H. ; Artzt, Karen ; Lindahl, Kirsten Fischer ; Dautigny, André. / Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex. In: Proceedings of the National Academy of Sciences of the United States of America. 1993 ; Vol. 90, No. 17. pp. 7990-7994.
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