Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia

Kirthi R. Kumar; Prasad Koduru; Charles Timmons; Sara Monaghan; Maryellen Cavalier; Hung S. Luu

doi:10.1002/pbc.24645

Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia

Kirthi R. Kumar, Prasad Koduru, Charles Timmons, Sara Monaghan, Maryellen Cavalier, Hung S. Luu

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146-E148.

Original language	English (US)
Pages (from-to)	E146-E148
Journal	Pediatric Blood and Cancer
Volume	60
Issue number	11
DOIs	https://doi.org/10.1002/pbc.24645
State	Published - Nov 2013

Keywords

Chronic myelogenous leukemia
Cytogenetics
Molecular genetics
Myelodysplastic syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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title = "Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia",

abstract = "Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146-E148.",

keywords = "Chronic myelogenous leukemia, Cytogenetics, Molecular genetics, Myelodysplastic syndrome",

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AU - Kumar, Kirthi R.

AU - Koduru, Prasad

AU - Timmons, Charles

AU - Monaghan, Sara

AU - Cavalier, Maryellen

AU - Luu, Hung S.

PY - 2013/11

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N2 - Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146-E148.

AB - Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146-E148.

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KW - Cytogenetics

KW - Molecular genetics

KW - Myelodysplastic syndrome

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Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia

Abstract

Keywords

ASJC Scopus subject areas

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