TY - JOUR
T1 - Myeloid neoplasm with t(3;8)(q26;q24)
T2 - Report of six cases and review of the literature
AU - Xu, Xiangdong
AU - Su, Mu
AU - Levy, Norman B.
AU - Mohtashamian, Arash
AU - Monaghan, Sara
AU - Kaur, Prabhjot
AU - Zaremba, Charles
AU - Garcia, Rolando
AU - Broome, H. Elizabeth
AU - Dell'Aquila, Marie L.
AU - Wang, Huan You
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Balanced translocation between chromosomes 3q26 and 8q24 is a very rare event. Here we report six patients with t(3;8)(q26;q24) either as a sole or as a part of genetic abnormalities. Five of the six patients were men with ages ranging from 41 to 84 years old. One patient had a long history of granulocyte colony stimulating factor (G-CSF) treatment. Three of the patients were initially diagnosed with acute myeloid leukemia, two with myelodysplastic syndrome and one with chronic myelogenous leukemia with blast crisis. The peripheral blood in all patients showed severe to moderate anemia; one had absolute neutropenia, one with neutrophilia; four had thrombocytopenia, two with thrombocytosis. The bone marrows from all patients showed dysmegakaryopoiesis with additional erythroid (three patients) and granulocytic (two patients) dysplasia. Cytogenetics revealed t(3;8)(q26;q24) as the sole abnormality in three patients. The majority of patients (4/6) had a poor clinical course, with an average survival of 10 months.
AB - Balanced translocation between chromosomes 3q26 and 8q24 is a very rare event. Here we report six patients with t(3;8)(q26;q24) either as a sole or as a part of genetic abnormalities. Five of the six patients were men with ages ranging from 41 to 84 years old. One patient had a long history of granulocyte colony stimulating factor (G-CSF) treatment. Three of the patients were initially diagnosed with acute myeloid leukemia, two with myelodysplastic syndrome and one with chronic myelogenous leukemia with blast crisis. The peripheral blood in all patients showed severe to moderate anemia; one had absolute neutropenia, one with neutrophilia; four had thrombocytopenia, two with thrombocytosis. The bone marrows from all patients showed dysmegakaryopoiesis with additional erythroid (three patients) and granulocytic (two patients) dysplasia. Cytogenetics revealed t(3;8)(q26;q24) as the sole abnormality in three patients. The majority of patients (4/6) had a poor clinical course, with an average survival of 10 months.
KW - Acute myeloid leukemia
KW - EVI1
KW - MDS1
KW - Myeloid dysplastic syndrome
KW - T(3;8)(q26;q24)
UR - http://www.scopus.com/inward/record.url?scp=84912091045&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912091045&partnerID=8YFLogxK
U2 - 10.3109/10428194.2013.878460
DO - 10.3109/10428194.2013.878460
M3 - Article
C2 - 24397594
AN - SCOPUS:84912091045
VL - 55
SP - 2532
EP - 2537
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 11
ER -