Myogenesis and Rhabdomyosarcoma: The Jekyll and Hyde of Skeletal Muscle

Raya Saab, Sheri L. Spunt, Stephen X. Skapek

Research output: Book/ReportBook

48 Citations (Scopus)

Abstract

Rhabdomyosarcoma, a neoplasm composed of skeletal myoblast-like cells, represents the most common soft tissue sarcoma in children. The application of intensive chemotherapeutics and refined surgical and radiation therapy approaches have improved survival for children with localized disease over the past 3 decades; however, these approaches have not improved the dismal outcome for children with metastatic and recurrent rhabdomyosarcoma. Elegant studies have defined the molecular mechanisms driving skeletal muscle lineage commitment and differentiation, and the machinery that couples differentiation with irreversible cell proliferation arrest. Further, detailed molecular analyses indicate that rhabdomyosarcoma cells have lost the capacity to fully differentiate when challenged to do so in experimental models. We review the intersection of normal skeletal muscle developmental biology and the molecular genetic defects in rhabdomyosarcoma with the underlying premise that understanding how the differentiation process has gone awry will lead to new treatment strategies aimed at promoting myogenic differentiation and concomitant cell cycle arrest.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages38
Volume94
EditionC
DOIs
StatePublished - 2011

Publication series

NameCurrent Topics in Developmental Biology
No.C
Volume94
ISSN (Print)00702153

Fingerprint

Rhabdomyosarcoma
Muscle Development
Skeletal Muscle
Skeletal Myoblasts
Developmental Biology
Cell Cycle Checkpoints
Sarcoma
Molecular Biology
Theoretical Models
Radiotherapy
Cell Proliferation
Neoplasms
Therapeutics

Keywords

  • Muscle differentiation
  • Rhabdomyosarcoma
  • Skeletal myogenesis

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

Cite this

Saab, R., Spunt, S. L., & Skapek, S. X. (2011). Myogenesis and Rhabdomyosarcoma: The Jekyll and Hyde of Skeletal Muscle. (C ed.) (Current Topics in Developmental Biology; Vol. 94, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-12-380916-2.00007-3

Myogenesis and Rhabdomyosarcoma : The Jekyll and Hyde of Skeletal Muscle. / Saab, Raya; Spunt, Sheri L.; Skapek, Stephen X.

C ed. Unknown Publisher, 2011. 38 p. (Current Topics in Developmental Biology; Vol. 94, No. C).

Research output: Book/ReportBook

Saab, R, Spunt, SL & Skapek, SX 2011, Myogenesis and Rhabdomyosarcoma: The Jekyll and Hyde of Skeletal Muscle. Current Topics in Developmental Biology, no. C, vol. 94, vol. 94, C edn, Unknown Publisher. https://doi.org/10.1016/B978-0-12-380916-2.00007-3
Saab R, Spunt SL, Skapek SX. Myogenesis and Rhabdomyosarcoma: The Jekyll and Hyde of Skeletal Muscle. C ed. Unknown Publisher, 2011. 38 p. (Current Topics in Developmental Biology; C). https://doi.org/10.1016/B978-0-12-380916-2.00007-3
Saab, Raya ; Spunt, Sheri L. ; Skapek, Stephen X. / Myogenesis and Rhabdomyosarcoma : The Jekyll and Hyde of Skeletal Muscle. C ed. Unknown Publisher, 2011. 38 p. (Current Topics in Developmental Biology; C).
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