Myomaker is essential for muscle regeneration

Douglas P. Millay, Lillian B. Sutherland, Rhonda Bassel-Duby, Eric N. Olson

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Regeneration of injured adult skeletal muscle involves fusion of activated satellite cells to form new myofibers. Myomaker is a muscle-specific membrane protein required for fusion of embryonic myoblasts, but its potential involvement in adult muscle regeneration has not been explored. We show that myogenic basic helix- loop-helix (bHLH) transcription factors induce myomaker expression in satellite cells during acute and chronic muscle regeneration. Moreover, genetic deletion of myomaker in adult satellite cells completely abolishes muscle regeneration, resulting in severe muscle destruction after injury. Myomaker is the only muscle-specific protein known to be absolutely essential for fusion of embryonic and adult myoblasts.

Original languageEnglish (US)
Pages (from-to)1641-1646
Number of pages6
JournalGenes and Development
Volume28
Issue number15
DOIs
StatePublished - 2014

Keywords

  • E-box elements
  • Fusion
  • Muscle regeneration
  • Myogenesis
  • Myomaker

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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