Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Yan Ning Qiao, Wei Qi He, Cai Ping Chen, Cheng Hai Zhang, Wei Zhao, Pei Wang, Lin Zhang, Yan Ze Wu, Xiao Yang, Ya Jing Peng, Ji Min Gao, Kristine E. Kamm, James T. Stull, Min Sheng Zhu

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

Original languageEnglish (US)
Pages (from-to)22512-22523
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

Fingerprint

Myosin-Light-Chain Phosphatase
Blood pressure
Vascular Smooth Muscle
Muscle
Blood Pressure
Phosphorylation
Myosins
Smooth Muscle Myosins
Maintenance

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. / Qiao, Yan Ning; He, Wei Qi; Chen, Cai Ping; Zhang, Cheng Hai; Zhao, Wei; Wang, Pei; Zhang, Lin; Wu, Yan Ze; Yang, Xiao; Peng, Ya Jing; Gao, Ji Min; Kamm, Kristine E.; Stull, James T.; Zhu, Min Sheng.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22512-22523.

Research output: Contribution to journalArticle

Qiao, YN, He, WQ, Chen, CP, Zhang, CH, Zhao, W, Wang, P, Zhang, L, Wu, YZ, Yang, X, Peng, YJ, Gao, JM, Kamm, KE, Stull, JT & Zhu, MS 2014, 'Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22512-22523. https://doi.org/10.1074/jbc.M113.525444
Qiao, Yan Ning ; He, Wei Qi ; Chen, Cai Ping ; Zhang, Cheng Hai ; Zhao, Wei ; Wang, Pei ; Zhang, Lin ; Wu, Yan Ze ; Yang, Xiao ; Peng, Ya Jing ; Gao, Ji Min ; Kamm, Kristine E. ; Stull, James T. ; Zhu, Min Sheng. / Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 32. pp. 22512-22523.
@article{7062f068f61341cb8b52e29ef5874189,
title = "Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure",
abstract = "Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.",
author = "Qiao, {Yan Ning} and He, {Wei Qi} and Chen, {Cai Ping} and Zhang, {Cheng Hai} and Wei Zhao and Pei Wang and Lin Zhang and Wu, {Yan Ze} and Xiao Yang and Peng, {Ya Jing} and Gao, {Ji Min} and Kamm, {Kristine E.} and Stull, {James T.} and Zhu, {Min Sheng}",
year = "2014",
month = "8",
day = "8",
doi = "10.1074/jbc.M113.525444",
language = "English (US)",
volume = "289",
pages = "22512--22523",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "32",

}

TY - JOUR

T1 - Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

AU - Qiao, Yan Ning

AU - He, Wei Qi

AU - Chen, Cai Ping

AU - Zhang, Cheng Hai

AU - Zhao, Wei

AU - Wang, Pei

AU - Zhang, Lin

AU - Wu, Yan Ze

AU - Yang, Xiao

AU - Peng, Ya Jing

AU - Gao, Ji Min

AU - Kamm, Kristine E.

AU - Stull, James T.

AU - Zhu, Min Sheng

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

AB - Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

UR - http://www.scopus.com/inward/record.url?scp=84905852265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905852265&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.525444

DO - 10.1074/jbc.M113.525444

M3 - Article

C2 - 24951589

AN - SCOPUS:84905852265

VL - 289

SP - 22512

EP - 22523

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 32

ER -