Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Yan Ning Qiao; Wei Qi He; Cai Ping Chen; Cheng Hai Zhang; Wei Zhao; Pei Wang; Lin Zhang; Yan Ze Wu; Xiao Yang; Ya Jing Peng; Ji Min Gao; Kristine E. Kamm; James T. Stull; Min Sheng Zhu

doi:10.1074/jbc.M113.525444

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Yan Ning Qiao, Wei Qi He, Cai Ping Chen, Cheng Hai Zhang, Wei Zhao, Pei Wang, Lin Zhang, Yan Ze Wu, Xiao Yang, Ya Jing Peng, Ji Min Gao, Kristine E. Kamm, James T. Stull, Min Sheng Zhu

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

Original language	English (US)
Pages (from-to)	22512-22523
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M113.525444
State	Published - Aug 8 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Qiao, Y. N., He, W. Q., Chen, C. P., Zhang, C. H., Zhao, W., Wang, P., Zhang, L., Wu, Y. Z., Yang, X., Peng, Y. J., Gao, J. M., Kamm, K. E., Stull, J. T., & Zhu, M. S. (2014). Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. Journal of Biological Chemistry, 289(32), 22512-22523. https://doi.org/10.1074/jbc.M113.525444

Qiao, YN, He, WQ, Chen, CP, Zhang, CH, Zhao, W, Wang, P, Zhang, L, Wu, YZ, Yang, X, Peng, YJ, Gao, JM, Kamm, KE , Stull, JT & Zhu, MS 2014, 'Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22512-22523. https://doi.org/10.1074/jbc.M113.525444

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title = "Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure",

abstract = "Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.",

author = "Qiao, {Yan Ning} and He, {Wei Qi} and Chen, {Cai Ping} and Zhang, {Cheng Hai} and Wei Zhao and Pei Wang and Lin Zhang and Wu, {Yan Ze} and Xiao Yang and Peng, {Ya Jing} and Gao, {Ji Min} and Kamm, {Kristine E.} and Stull, {James T.} and Zhu, {Min Sheng}",

year = "2014",

month = aug,

day = "8",

doi = "10.1074/jbc.M113.525444",

language = "English (US)",

volume = "289",

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journal = "Journal of Biological Chemistry",

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T1 - Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

AU - Qiao, Yan Ning

AU - He, Wei Qi

AU - Chen, Cai Ping

AU - Zhang, Cheng Hai

AU - Zhao, Wei

AU - Wang, Pei

AU - Zhang, Lin

AU - Wu, Yan Ze

AU - Yang, Xiao

AU - Peng, Ya Jing

AU - Gao, Ji Min

AU - Kamm, Kristine E.

AU - Stull, James T.

AU - Zhu, Min Sheng

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

AB - Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

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JO - Journal of Biological Chemistry

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Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

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