Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

Yan Ning Qiao, Wei Qi He, Cai Ping Chen, Cheng Hai Zhang, Wei Zhao, Pei Wang, Lin Zhang, Yan Ze Wu, Xiao Yang, Ya Jing Peng, Ji Min Gao, Kristine E. Kamm, James T. Stull, Min Sheng Zhu

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Background: MYPT1 is a regulatory subunit of myosin phosphatase. Results: Deleting MYPT1 in vascular smooth muscle enhances myosin phosphorylation, contractility, and blood pressure. Conclusion: Genetic evidence shows MYPT1 plays a role in modulating vascular smooth muscle contractility. Significance: Although MYPT1 is not essential for vascular smooth muscle contractility, it contributes to blood pressure maintenance in vivo through signaling to myosin phosphorylation.

Original languageEnglish (US)
Pages (from-to)22512-22523
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Qiao, Y. N., He, W. Q., Chen, C. P., Zhang, C. H., Zhao, W., Wang, P., Zhang, L., Wu, Y. Z., Yang, X., Peng, Y. J., Gao, J. M., Kamm, K. E., Stull, J. T., & Zhu, M. S. (2014). Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. Journal of Biological Chemistry, 289(32), 22512-22523. https://doi.org/10.1074/jbc.M113.525444