Myosin phosphorylation and the control of myometrial contraction/relaxation

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

In summary, phosphorylation of the regulatory light chain of myosin by Ca2+/CaM-dependent MLCK plays an important role in smooth muscle contraction. Although there have been major advances in our understanding of the regulation and physiological functions of contractile proteins in smooth muscle in recent years, very little information exists on the functional status of these proteins in human myometrium during pregnancy. The simple view that contractile force in smooth muscle is proportionate to cytoplasmic Ca2+ concentrations (Cai 2+) and myosin light chain phosphorylation is now more complex as more experiments provide insights into mechanisms of regulation of the contractile elements. MLCK can be phosphorylated, which desensitizes its activation by Ca2+/CaM, and protein phosphatase activity toward myosin may also be regulated. Examples in smooth muscle tissue are sparse, and the different mechanisms by which these processes may be adapted in uterine smooth muscle during pregnancy are not well-defined. Much research is needed to define further the cellular, biochemical, and molecular basis for these physiological processes involved in the regulation of uterine smooth muscle contraction and relaxation.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalSeminars in Perinatology
Volume19
Issue number1
DOIs
StatePublished - 1995

Fingerprint

Uterine Contraction
Myosins
Smooth Muscle
Phosphorylation
Myometrium
Myosin Light Chains
Muscle Contraction
Physiological Phenomena
Contractile Proteins
Pregnancy
Muscle Relaxation
Phosphoprotein Phosphatases
Muscles
Research
Proteins

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Myosin phosphorylation and the control of myometrial contraction/relaxation. / Word, R. Ann.

In: Seminars in Perinatology, Vol. 19, No. 1, 1995, p. 3-14.

Research output: Contribution to journalArticle

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