NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation

Meeyoung Park, Qin Li, Nikolay Shcheynikov, Weizong Zeng, Shmuel Muallem

Research output: Contribution to journalArticle

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Abstract

Boron is a vital micronutrient in plants and may be essential for animal growth and development. Whereas the role of boron in the life cycle of plants is well documented, nothing is known about boron homeostasis and function in animal cells. NaBC1, the mammalian homolog of AtBor1, is a borate transporter. In the absence of borate, NaBC1 conducts Na+ and OH- (H+), while in the presence of borate, NaBC1 functions as an electrogenic, voltage-regulated, Na+-coupled B(OH)4 - transporter. At low concentrations, borate activated the MAPK pathway to stimulate cell growth and proliferation, and at high concentrations, it was toxic. Accordingly, overexpression of NaBC1 shifted both effects of borate to the left, whereas knockdown of NaBC1 halted cell growth and proliferation. These findings may reveal a previously unrecognized role for NaBC1 in borate homeostasis and open the way to better understanding of the many presumed physiological roles of borate in animals.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalMolecular Cell
Volume16
Issue number3
DOIs
StatePublished - Nov 5 2004

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Borates
Boron
Homeostasis
Cell Proliferation
Growth
Micronutrients
Poisons
Life Cycle Stages
Growth and Development

ASJC Scopus subject areas

  • Molecular Biology

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NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. / Park, Meeyoung; Li, Qin; Shcheynikov, Nikolay; Zeng, Weizong; Muallem, Shmuel.

In: Molecular Cell, Vol. 16, No. 3, 05.11.2004, p. 331-341.

Research output: Contribution to journalArticle

Park, Meeyoung ; Li, Qin ; Shcheynikov, Nikolay ; Zeng, Weizong ; Muallem, Shmuel. / NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. In: Molecular Cell. 2004 ; Vol. 16, No. 3. pp. 331-341.
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