Na+/H+ exchanger

M. Kuro-o

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Recent investigations have revealed that an enhancement of Na+/H+ exchange activity is a frequently observed ion transport abnormality in hypertensive patients. To test the hypothesis that increased Na+/H+ exchange causes hypertension, we produced transgenic mice overexpressing Na+/H+ exchanger and analyzed their Na+ metabolism and blood pressure. Urinary excretion of water and Na+ was significantly decreased in transgenic mice and systolic blood pressure was elevated after salt loading. The impaired Na+ excretion suggested that the Na+/H+ exchanger overexpressed in the renal tubules increased Na+ reabsorption, which caused a blood pressure elevation by Na+ retention after excessive salt intake. Our results demonstrate that overexpression of Na+/H+ exchanger can be a genetic factor for salt-sensitive hypertension.

Original languageEnglish (US)
Pages (from-to)607-611
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number3
StatePublished - Mar 1996

ASJC Scopus subject areas

  • Medicine(all)


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