Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Joseph D. Miller, Samuel G. Speciale, Brian A. McMillen, Dwight C. German

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalEuropean Journal of Pharmacology
Volume98
Issue number3-4
DOIs
StatePublished - Mar 2 1984

Fingerprint

Frontal Lobe
Naloxone
Opiate Alkaloids
Foot
Shock
Dopamine
Caudate Nucleus
Dopaminergic Neurons
Nucleus Accumbens
Opioid Analgesics

Keywords

  • Dopamine
  • Frontal cortex
  • Naloxone
  • Opiates
  • Stress

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism. / Miller, Joseph D.; Speciale, Samuel G.; McMillen, Brian A.; German, Dwight C.

In: European Journal of Pharmacology, Vol. 98, No. 3-4, 02.03.1984, p. 437-439.

Research output: Contribution to journalArticle

Miller, Joseph D. ; Speciale, Samuel G. ; McMillen, Brian A. ; German, Dwight C. / Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism. In: European Journal of Pharmacology. 1984 ; Vol. 98, No. 3-4. pp. 437-439.
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