Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Joseph D. Miller, Samuel G. Speciale, Brian A. McMillen, Dwight C. German

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

Original languageEnglish (US)
Pages (from-to)437-439
Number of pages3
JournalEuropean Journal of Pharmacology
Volume98
Issue number3-4
DOIs
StatePublished - Mar 2 1984

Keywords

  • Dopamine
  • Frontal cortex
  • Naloxone
  • Opiates
  • Stress

ASJC Scopus subject areas

  • Pharmacology

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