Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Joseph D. Miller; Samuel G. Speciale; Brian A. McMillen; Dwight C. German

doi:10.1016/0014-2999(84)90295-4

Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Joseph D. Miller, Samuel G. Speciale, Brian A. McMillen, Dwight C. German

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

Original language	English (US)
Pages (from-to)	437-439
Number of pages	3
Journal	European Journal of Pharmacology
Volume	98
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(84)90295-4
State	Published - Mar 2 1984

Keywords

Dopamine
Frontal cortex
Naloxone
Opiates
Stress

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(84)90295-4

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title = "Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism",

abstract = "Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.",

keywords = "Dopamine, Frontal cortex, Naloxone, Opiates, Stress",

author = "Miller, {Joseph D.} and Speciale, {Samuel G.} and McMillen, {Brian A.} and German, {Dwight C.}",

note = "Funding Information: This research supported by USPHS grants MH-30546 and MH-35020. The authors wish to thank Laura Boynton and Mildred Kreitzer for secretarial assistance and Janet Harkness for technical assistance.",

year = "1984",

month = mar,

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doi = "10.1016/0014-2999(84)90295-4",

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T1 - Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

AU - Miller, Joseph D.

AU - Speciale, Samuel G.

AU - McMillen, Brian A.

AU - German, Dwight C.

N1 - Funding Information: This research supported by USPHS grants MH-30546 and MH-35020. The authors wish to thank Laura Boynton and Mildred Kreitzer for secretarial assistance and Janet Harkness for technical assistance.

PY - 1984/3/2

Y1 - 1984/3/2

N2 - Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

AB - Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.

KW - Dopamine

KW - Frontal cortex

KW - Naloxone

KW - Opiates

KW - Stress

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3-4

ER -

Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism

Abstract

Keywords

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