Nano-therapeutics for the lung: State-of-the-art and future perspectives

Roshni Iyer, Connie C W Hsia, Kytai T. Nguyen

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Inhalation of aerosolized compounds is a popular, non-invasive route for the targeted delivery of therapeutic molecules to the lung. Various types of nanoparticles have been used as carriers to facilitate drug uptake and intracellular action in order to treat lung diseases and/or to facilitate lung repair and growth. These include polymeric nanoparticles, liposomes, and dendrimers, among many others. In addition, nanoparticles are sometimes used in combination with small molecules, cytokines, growth factors, and/or pluripotent stem cells. Here we review the rationale and state-of-the-art nanotechnology for pulmonary drug delivery, with particular attention to new technological developments and approaches as well as the challenges associated with them, the emerging advances, and opportunities for future development in this field.

Original languageEnglish (US)
Pages (from-to)5233-5244
Number of pages12
JournalCurrent Pharmaceutical Design
Volume21
Issue number36
StatePublished - Oct 1 2015

Keywords

  • Aerosolization
  • Growth factors
  • Inhalation
  • Lung disease
  • Lung repair
  • Nanoparticles
  • Pulmonary delivery
  • Stem cells

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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