Nanoindentation of Pseudomonas aeruginosa bacterial biofilm using atomic force microscopy

Mahmoud Baniasadi, Zhe Xu, Leah Gandee, Yingjie Du, Hongbing Lu, Philippe Zimmern, Majid Minary-Jolandan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bacterial biofilms are a source of many chronic infections. Biofilms and their inherent resistance to antibiotics are attributable to a range of health issues including affecting prosthetic implants, hospital-acquired infections, and wound infection. Mechanical properties of biofilm, in particular, at micro- and nanoscales, are governed by microstructures and porosity of the biofilm, which in turn may contribute to their inherent antibiotic resistance. We utilize atomic force microscopy (AFM)-based nanoindentation and finite element simulation to investigate the nanoscale mechanical properties of Pseudomonas aeruginosa bacterial biofilm. This biofilm was derived from human samples and represents a medically relevant model.

Original languageEnglish (US)
Article number045411
JournalMaterials Research Express
Volume1
Issue number4
DOIs
StatePublished - Dec 1 2015

Fingerprint

Biofilms
Nanoindentation
Atomic force microscopy
Antibiotics
Anti-Bacterial Agents
Mechanical properties
Porosity
Health
Microstructure

Keywords

  • Atomic force microscope
  • Bacterial biofilm
  • Nanoindentation
  • Nanomechanical properties
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Metals and Alloys
  • Polymers and Plastics
  • Surfaces, Coatings and Films

Cite this

Nanoindentation of Pseudomonas aeruginosa bacterial biofilm using atomic force microscopy. / Baniasadi, Mahmoud; Xu, Zhe; Gandee, Leah; Du, Yingjie; Lu, Hongbing; Zimmern, Philippe; Minary-Jolandan, Majid.

In: Materials Research Express, Vol. 1, No. 4, 045411, 01.12.2015.

Research output: Contribution to journalArticle

Baniasadi, Mahmoud ; Xu, Zhe ; Gandee, Leah ; Du, Yingjie ; Lu, Hongbing ; Zimmern, Philippe ; Minary-Jolandan, Majid. / Nanoindentation of Pseudomonas aeruginosa bacterial biofilm using atomic force microscopy. In: Materials Research Express. 2015 ; Vol. 1, No. 4.
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