TY - JOUR
T1 - Nanomedicine approaches to improve cancer immunotherapy
AU - Qiu, Hui
AU - Min, Yuanzeng
AU - Rodgers, Zach
AU - Zhang, Longzhen
AU - Wang, Andrew Z.
N1 - Funding Information:
This work was supported by National Institutes of Health/National Cancer Institute (R01CA178748-01) and National Institutes of Health/National Cancer Institute (U54CA198999, Carolina Center of Cancer Nanotechnology Excellence (CCNE)-Nano Approaches to Modulate Host Cell Response for Cancer Therapy). Andrew Z. Wang was supported by funding from the NIH/NCI (R21 CA182322). Longzhen Zhang was supported by the National Natural Science Foundation of China (No. 81372424) and the Foundation Research Project of Jiangsu Province (No. BK20131131).
Publisher Copyright:
© 2017 Wiley Periodicals, Inc.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Significant advances have been made in the field of cancer immunotherapy by orchestrating the body's immune system to eradicate cancer cells. However, safety and efficacy concerns stemming from the systemic delivery of immunomodulatory compounds limits cancer immunotherapies expansion and application. In this context, nanotechnology presents a number of advantages, such as targeted delivery to immune cells, enhanced clinical outcomes, and reduced adverse events, which may aid in the delivery of cancer vaccines and immunomodulatory agents. With this in mind, a diverse range of nanomaterials with different physicochemical characteristics have been developed to stimulate the immune system and battle cancer. In this review, we will focus on some recent developments and the potential advantages of utilizing nanotechnology within the field of cancer immunotherapy. WIREs Nanomed Nanobiotechnol 2017, 9:e1456. doi: 10.1002/wnan.1456. For further resources related to this article, please visit the WIREs website.
AB - Significant advances have been made in the field of cancer immunotherapy by orchestrating the body's immune system to eradicate cancer cells. However, safety and efficacy concerns stemming from the systemic delivery of immunomodulatory compounds limits cancer immunotherapies expansion and application. In this context, nanotechnology presents a number of advantages, such as targeted delivery to immune cells, enhanced clinical outcomes, and reduced adverse events, which may aid in the delivery of cancer vaccines and immunomodulatory agents. With this in mind, a diverse range of nanomaterials with different physicochemical characteristics have been developed to stimulate the immune system and battle cancer. In this review, we will focus on some recent developments and the potential advantages of utilizing nanotechnology within the field of cancer immunotherapy. WIREs Nanomed Nanobiotechnol 2017, 9:e1456. doi: 10.1002/wnan.1456. For further resources related to this article, please visit the WIREs website.
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U2 - 10.1002/wnan.1456
DO - 10.1002/wnan.1456
M3 - Review article
C2 - 28296286
AN - SCOPUS:85015251383
SN - 1939-5116
VL - 9
JO - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
IS - 5
M1 - e1456
ER -