Nanomedicine based on nucleic acids: Pharmacokinetic and pharmacodynamic perspectives

Chenguang Zhou, Zhaogang Yang, Lesheng Teng

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Nanoparticles have shown great promise for improving the efficacy of nucleic acid drugs that lack permeability and bioavailability needed for reaching their intracellular site of action. The pharmacokinetics of the nucleic acid nanomedicines contributes greatly to their pharmacodynamic and toxicity characteristics. The pharmacokinetics of nanomedicines is determined by their physiochemical properties, such as particle size, shape, surface charge, and surface modifications. This review presented the pharmacokinetic and pharmacodynamic perspectives of nucleic acid nanomedicines. The cellular trafficking of the nucleic acid nanomedicines after cellular uptake is also discussed. In addition, the review puts forward potential strategies for circumventing biological barriers to delivering and releasing nucleic acid drugs into their intracellular site of action, and perspectives in this rapidly evolving field.

Original languageEnglish (US)
Article numberA08
Pages (from-to)829-838
Number of pages10
JournalCurrent Pharmaceutical Biotechnology
Volume15
Issue number9
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Antisense oligonucleotide
  • Gene therapy
  • Intracellular trafficking
  • MicroRNA
  • Nanomedicine
  • Pharmacodynamic
  • Pharmacokinetic
  • Plasmid DNA
  • Small interfering RNA

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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