TY - JOUR
T1 - Nanonization strategies for poorly water-soluble drugs
AU - Chen, Huabing
AU - Khemtong, Chalermchai
AU - Yang, Xiangliang
AU - Chang, Xueling
AU - Gao, Jinming
N1 - Funding Information:
We are grateful for financial support from the National Cancer Institute (RO1 CA129011) to J.G. and the MOST 973 program of China (No. 2006CB933301) to X.Y. C.K. thanks the Department of Defense Breast Cancer Research Program for a Multidisciplinary Postdoctoral Award (W81XWH-06-1-0751). The authors also thank Baran D. Sumer for helpful discussions.
PY - 2011/4
Y1 - 2011/4
N2 - Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor® EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.
AB - Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor® EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.
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U2 - 10.1016/j.drudis.2010.02.009
DO - 10.1016/j.drudis.2010.02.009
M3 - Review article
C2 - 20206289
AN - SCOPUS:79953685905
SN - 1359-6446
VL - 16
SP - 354
EP - 360
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 7-8
ER -