Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo

Feifei Yang, Yusra Medik, Liantao Li, Xi Tian, Dong Fu, Kim L.R. Brouwer, Kyle Wagner, Bo Sun, Hossein Sendi, Yu Mi, Andrew Z. Wang

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of nanotherapeutics beyond the intrinsic hepatotoxicity of nanoparticles (NPs) are poorly understood. Because of this knowledge gap, clinical translation efforts have avoided hepatotoxic molecules. By examining the hepatotoxicity of nanoformulations of known hepatotoxic compounds, it is demonstrated that nanotherapeutics are associated with lower hepatotoxicity than their small-molecule counterparts. It is also found that the reduced hepatotoxicity is related to the uptake of nanotherapeutics by macrophages in the liver. These findings can facilitate further development and clinical translation of nanotherapeutics.

Original languageEnglish (US)
Article number1906360
JournalSmall
Volume16
Issue number7
DOIs
StatePublished - Feb 1 2020
Externally publishedYes

Keywords

  • clinical translation
  • hepatotoxicity
  • macrophage uptake
  • nanomedicine
  • nanotoxicity

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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