TY - JOUR
T1 - Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases
AU - Iyer, Roshni
AU - Kuriakose, Aneetta E.
AU - Yaman, Serkan
AU - Su, Lee Chun
AU - Shan, Dingying
AU - Yang, Jian
AU - Liao, Jun
AU - Tang, Liping
AU - Banerjee, Subhash
AU - Xu, Hao
AU - Nguyen, Kytai T.
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1/10
Y1 - 2019/1/10
N2 - Nanoparticles (NPs) can be used to locally deliver anti-restenosis drugs when they are infused directly to the injured arteries after intervention procedures such as angioplasty. However, the efficacy of transferring NPs via infusion to the arterial wall is limited, at least partially, due to poor NP retention on the inner artery wall. To improve NP retention, angioplasty balloons coated with drug-loaded NPs were fabricated via either layer-by-layer (LbL) electrostatic coating or acrylic-based hydrogel (AAH) coating techniques. Three types of NPs, namely poly (lactide-co-glycolide) (PLGA), biodegradable photo-luminescent PLGA and urethane doped polyester were studied. The transfer efficacy of NPs from various coatings to the arterial wall were further evaluated to find the optimal coating conditions. The ex vivo NP transfer studies showed significantly more NPs being transferred to the rat arterial wall after the angioplasty procedure by the AAH coating (95% transfer efficiency) compared to that of the LbL technique (60%) and dip coating (20%) under flow conditions (10 dyn/cm 2 ). Our results suggest that the AAH coating of drug-loaded NPs on the angioplasty balloon could potentially provide superior retention of drug-loaded NPs onto the arterial wall for a better local delivery of drug-loaded NPs to effectively treat arterial diseases.
AB - Nanoparticles (NPs) can be used to locally deliver anti-restenosis drugs when they are infused directly to the injured arteries after intervention procedures such as angioplasty. However, the efficacy of transferring NPs via infusion to the arterial wall is limited, at least partially, due to poor NP retention on the inner artery wall. To improve NP retention, angioplasty balloons coated with drug-loaded NPs were fabricated via either layer-by-layer (LbL) electrostatic coating or acrylic-based hydrogel (AAH) coating techniques. Three types of NPs, namely poly (lactide-co-glycolide) (PLGA), biodegradable photo-luminescent PLGA and urethane doped polyester were studied. The transfer efficacy of NPs from various coatings to the arterial wall were further evaluated to find the optimal coating conditions. The ex vivo NP transfer studies showed significantly more NPs being transferred to the rat arterial wall after the angioplasty procedure by the AAH coating (95% transfer efficiency) compared to that of the LbL technique (60%) and dip coating (20%) under flow conditions (10 dyn/cm 2 ). Our results suggest that the AAH coating of drug-loaded NPs on the angioplasty balloon could potentially provide superior retention of drug-loaded NPs onto the arterial wall for a better local delivery of drug-loaded NPs to effectively treat arterial diseases.
KW - Angioplasty balloon coating
KW - Drug eluting balloons
KW - Hydrogel
KW - Layer-by-layer
KW - Nanoparticle coating
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U2 - 10.1016/j.ijpharm.2018.11.011
DO - 10.1016/j.ijpharm.2018.11.011
M3 - Article
C2 - 30408532
AN - SCOPUS:85056450845
SN - 0378-5173
VL - 554
SP - 212
EP - 223
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
ER -