Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases

Roshni Iyer, Aneetta E. Kuriakose, Serkan Yaman, Lee Chun Su, Dingying Shan, Jian Yang, Jun Liao, Liping Tang, Subhash Banerjee, Hao Xu, Kytai T. Nguyen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Nanoparticles (NPs) can be used to locally deliver anti-restenosis drugs when they are infused directly to the injured arteries after intervention procedures such as angioplasty. However, the efficacy of transferring NPs via infusion to the arterial wall is limited, at least partially, due to poor NP retention on the inner artery wall. To improve NP retention, angioplasty balloons coated with drug-loaded NPs were fabricated via either layer-by-layer (LbL) electrostatic coating or acrylic-based hydrogel (AAH) coating techniques. Three types of NPs, namely poly (lactide-co-glycolide) (PLGA), biodegradable photo-luminescent PLGA and urethane doped polyester were studied. The transfer efficacy of NPs from various coatings to the arterial wall were further evaluated to find the optimal coating conditions. The ex vivo NP transfer studies showed significantly more NPs being transferred to the rat arterial wall after the angioplasty procedure by the AAH coating (95% transfer efficiency) compared to that of the LbL technique (60%) and dip coating (20%) under flow conditions (10 dyn/cm2). Our results suggest that the AAH coating of drug-loaded NPs on the angioplasty balloon could potentially provide superior retention of drug-loaded NPs onto the arterial wall for a better local delivery of drug-loaded NPs to effectively treat arterial diseases.

Original languageEnglish (US)
Pages (from-to)212-223
Number of pages12
JournalInternational Journal of Pharmaceutics
Volume554
DOIs
Publication statusPublished - Jan 10 2019

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Keywords

  • Angioplasty balloon coating
  • Drug eluting balloons
  • Hydrogel
  • Layer-by-layer
  • Nanoparticle coating

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Iyer, R., Kuriakose, A. E., Yaman, S., Su, L. C., Shan, D., Yang, J., ... Nguyen, K. T. (2019). Nanoparticle eluting-angioplasty balloons to treat cardiovascular diseases. International Journal of Pharmaceutics, 554, 212-223. https://doi.org/10.1016/j.ijpharm.2018.11.011