TY - JOUR
T1 - Nanotechnology and aptamers
T2 - applications in drug delivery
AU - Levy-Nissenbaum, Etgar
AU - Radovic-Moreno, Aleksandar F.
AU - Wang, Andrew Z.
AU - Langer, Robert
AU - Farokhzad, Omid C.
N1 - Funding Information:
This work is supported by USA National Institute of Health grant CA119349 (R.L. and O.C.F.) and EB003647 (O.C.F.). E.L-N. was supported by a postdoctoral fellowship from the USA Department of Defense Prostate Cancer Research Program PtdCho 051156. A.F.R-M. would like to acknowledge support from the National Science Foundation Graduate Research Fellowship Program.
PY - 2008/8
Y1 - 2008/8
N2 - Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics. These properties will enable aptamers to facilitate innovative new nanotechnologies with applications in medicine. In this review, we will highlight recent developments in using aptamers in nanotechnology solutions for treating and diagnosing disease.
AB - Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics. These properties will enable aptamers to facilitate innovative new nanotechnologies with applications in medicine. In this review, we will highlight recent developments in using aptamers in nanotechnology solutions for treating and diagnosing disease.
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U2 - 10.1016/j.tibtech.2008.04.006
DO - 10.1016/j.tibtech.2008.04.006
M3 - Review article
C2 - 18571753
AN - SCOPUS:47049115502
SN - 0167-7799
VL - 26
SP - 442
EP - 449
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 8
ER -