Nanotechnology and aptamers: applications in drug delivery

Etgar Levy-Nissenbaum, Aleksandar F. Radovic-Moreno, Andrew Z. Wang, Robert Langer, Omid C. Farokhzad

Research output: Contribution to journalReview articlepeer-review

226 Scopus citations

Abstract

Nucleic acid ligands, also known as aptamers, are a class of macromolecules that are being used in several novel nanobiomedical applications. Aptamers are characterized by high affinity and specificity for their target, a versatile selection process, ease of chemical synthesis and a small physical size, which collectively make them attractive molecules for targeting diseases or as therapeutics. These properties will enable aptamers to facilitate innovative new nanotechnologies with applications in medicine. In this review, we will highlight recent developments in using aptamers in nanotechnology solutions for treating and diagnosing disease.

Original languageEnglish (US)
Pages (from-to)442-449
Number of pages8
JournalTrends in Biotechnology
Volume26
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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