TY - JOUR
T1 - Nanotechnology in radiation oncology
AU - Wang, Andrew Z.
AU - Tepper, Joel E.
N1 - Publisher Copyright:
© 2014 by American Society of Clinical Oncology.
PY - 2014/9/10
Y1 - 2014/9/10
N2 - Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively new branch of science. It has already made a significant impact on clinical medicine, especially in oncology. Nanomaterial has several characteristics that are ideal for oncology applications, including preferential accumulation in tumors, low distribution in normal tissues, biodistribution, pharmacokinetics, and clearance, that differ from those of small molecules. Because these properties are also well suited for applications in radiation oncology, nanomaterials have been used in many different areas of radiation oncology for imaging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio. In this article, we review the unique properties of nanomaterials that are favorable for oncology applications and examine the various applications of nanotechnology in radiation oncology. We also discuss the future directions of nanotechnology within the context of radiation oncology.
AB - Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively new branch of science. It has already made a significant impact on clinical medicine, especially in oncology. Nanomaterial has several characteristics that are ideal for oncology applications, including preferential accumulation in tumors, low distribution in normal tissues, biodistribution, pharmacokinetics, and clearance, that differ from those of small molecules. Because these properties are also well suited for applications in radiation oncology, nanomaterials have been used in many different areas of radiation oncology for imaging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio. In this article, we review the unique properties of nanomaterials that are favorable for oncology applications and examine the various applications of nanotechnology in radiation oncology. We also discuss the future directions of nanotechnology within the context of radiation oncology.
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U2 - 10.1200/JCO.2014.55.0699
DO - 10.1200/JCO.2014.55.0699
M3 - Review article
C2 - 25113769
AN - SCOPUS:84907015960
SN - 0732-183X
SP - 2879
EP - 2885
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 26
ER -