Nanotechnology in radiation oncology

Andrew Z. Wang, Joel E. Tepper

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively new branch of science. It has already made a significant impact on clinical medicine, especially in oncology. Nanomaterial has several characteristics that are ideal for oncology applications, including preferential accumulation in tumors, low distribution in normal tissues, biodistribution, pharmacokinetics, and clearance, that differ from those of small molecules. Because these properties are also well suited for applications in radiation oncology, nanomaterials have been used in many different areas of radiation oncology for imaging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio. In this article, we review the unique properties of nanomaterials that are favorable for oncology applications and examine the various applications of nanotechnology in radiation oncology. We also discuss the future directions of nanotechnology within the context of radiation oncology.

Original languageEnglish (US)
Pages (from-to)2879-2885
Number of pages7
JournalJournal of Clinical Oncology
Issue number26
DOIs
StatePublished - Sep 10 2014
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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