Naphthalocyanine-reconstituted LDL nanoparticles for in vivo cancer imaging and treatment

Liping Song, Hui Li, Ulas Sunar, Juan Chen, Ian Corbin, Arjun G. Yodh, Gang Zheng

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Low density lipoproteins (LDLs) are naturally occurring nanoparticles that are biocompatible, biodegradable and non-immunogenic. Moreover, the size of LDL particle is precisely controlled (∼22 nm) by its apoB-100 component, setting them apart from liposomes and lipid micelles. LDL particles have long been proposed as a nanocarrier for targeted delivery of diagnostics and therapeutics to LDL receptor (LDLR)-positive cancers. Here, we report the design and synthesis of a novel naphthalocyanine (Nc)-based photodynamic therapy (PDT) agent, SiNcBOA, and describe its efficient reconstitution into LDL core (100: 1 payload). Possessing a near-infrared (NIR) absorption wavelength (>800 mn) and extremely high extinction coefficient (>105 M-1 cm-1), SiNcBOA holds the promise of treating deeply seated tumors. Reconstituted LDL particles (r-Nc-LDL) maintain the size and shape of native LDL as determined by transmission electron microscopy, and also retain their LDLR-mediated uptake by cancer cells as demonstrated by confocal microscopy. Its preferential uptake by tumor vs normal tissue was confirmed in vivo by noninvasive optical imaging technique, demonstrating the feasibility of using this nanoparticle for NIR imaging-guided PDT of cancer.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalInternational Journal of Nanomedicine
Volume2
Issue number4
StatePublished - 2007

Keywords

  • Drug delivery
  • Lipoproteins
  • Nanoparticle
  • Naphthalocyanine
  • Near-infrared optical imaging
  • Photodynamic therapy

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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