@article{e77f413353b440b08c31e8b268ff7dd5,
title = "Nav1.8 neurons are involved in limiting acute phase responses to dietary fat",
abstract = "Objective and methods: Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. Results: While mice lacking sensory neurons displayed no differences in body weight, food intake, energy expenditure, or body composition compared to controls on chow diet, ablated mice developed an exaggerated inflammatory response to high-fat feeding characterized by bouts of weight loss, splenomegaly, elevated circulating interleukin-6 and hepatic serum amyloid A expression. This phenotype appeared to be directly mediated by the ingestion of saturated lipids. Conclusions: These data demonstrate that the Nav1.8-expressing afferent neurons are not essential for energy balance but are required for limiting the acute phase response caused by an obesogenic diet.",
keywords = "Deafferentation, Diphtheria toxin, Energy homeostasis, Inflammation, Nodose ganglion, Obesity",
author = "Swalpa Udit and Michael Burton and Rutkowski, {Joseph M.} and Syann Lee and Bookout, {Angie L.} and Scherer, {Philipp E.} and Elmquist, {Joel K.} and Laurent Gautron",
note = "Funding Information: We would like to thank Charlotte Lee, Danielle Lauzon, Ying Huang, Yang Liu, and Matthew Harper (UT Southwestern medical center) for their technical assistance. We are grateful to Dr. John Wood for providing us with Na v 1.8-Cre mice (6WIBR, University College London WC1E 6BT UK). We would like to thank the Mouse Metabolic Phenotyping Core at University of Texas Southwestern Medical Center at Dallas (supported by P01DK088761 , PL1 DK081182 , UL1RR024923 ). JKE supported by the NIH ( P01DK088761 ; RL1DK081185 ). PES was supported by the NIH ( R01-DK55758 and P01DK088761 ). Funding Information: We would like to thank Charlotte Lee, Danielle Lauzon, Ying Huang, Yang Liu, and Matthew Harper (UT Southwestern medical center) for their technical assistance. We are grateful to Dr. John Wood for providing us with Nav1.8-Cre mice (6WIBR, University College London WC1E 6BT UK). We would like to thank the Mouse Metabolic Phenotyping Core at University of Texas Southwestern Medical Center at Dallas (supported by P01DK088761, PL1 DK081182, UL1RR024923). JKE supported by the NIH (P01DK088761; RL1DK081185). PES was supported by the NIH (R01-DK55758 and P01DK088761). Publisher Copyright: {\textcopyright} 2017 The Authors",
year = "2017",
month = oct,
doi = "10.1016/j.molmet.2017.07.012",
language = "English (US)",
volume = "6",
pages = "1081--1091",
journal = "Molecular Metabolism",
issn = "2212-8778",
publisher = "Elsevier GmbH",
number = "10",
}