TY - JOUR
T1 - Na+/H+ Exchangers in Renal Regulation of Acid-Base Balance
AU - Bobulescu, I. Alexandru
AU - Moe, Orson W.
N1 - Funding Information:
Supported by grants from the National Institutes of Health (DK48482, DK20543 to O.W.M.), the National Kidney Foundation (to I.A.B.), the Charles and Jane Pak Research Fellowship (to I.A.B.), and the Simmons Family Foundation (to O.W.M.).
PY - 2006/9
Y1 - 2006/9
N2 - The kidney plays key roles in extracellular fluid pH homeostasis by reclaiming bicarbonate (HCO3-) filtered at the glomerulus and generating the consumed HCO3- by secreting protons (H+) into the urine (renal acidification). Sodium-proton exchangers (NHEs) are ubiquitous transmembrane proteins mediating the countertransport of Na+ and H+ across lipid bilayers. In mammals, NHEs participate in the regulation of cell pH, volume, and intracellular sodium concentration, as well as in transepithelial ion transport. Five of the 10 isoforms (NHE1-4 and NHE8) are expressed at the plasma membrane of renal epithelial cells. The best-studied isoform for acid-base homeostasis is NHE3, which mediates both HCO3- absorption and H+ excretion in the renal tubule. This article reviews some important aspects of NHEs in the kidney, with special emphasis on the role of renal NHE3 in the maintenance of acid-base balance.
AB - The kidney plays key roles in extracellular fluid pH homeostasis by reclaiming bicarbonate (HCO3-) filtered at the glomerulus and generating the consumed HCO3- by secreting protons (H+) into the urine (renal acidification). Sodium-proton exchangers (NHEs) are ubiquitous transmembrane proteins mediating the countertransport of Na+ and H+ across lipid bilayers. In mammals, NHEs participate in the regulation of cell pH, volume, and intracellular sodium concentration, as well as in transepithelial ion transport. Five of the 10 isoforms (NHE1-4 and NHE8) are expressed at the plasma membrane of renal epithelial cells. The best-studied isoform for acid-base homeostasis is NHE3, which mediates both HCO3- absorption and H+ excretion in the renal tubule. This article reviews some important aspects of NHEs in the kidney, with special emphasis on the role of renal NHE3 in the maintenance of acid-base balance.
KW - bicarbonate absorption
KW - renal acidification
KW - sodium/hydrogen exchange
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U2 - 10.1016/j.semnephrol.2006.07.001
DO - 10.1016/j.semnephrol.2006.07.001
M3 - Article
C2 - 17071327
AN - SCOPUS:33750375599
SN - 0270-9295
VL - 26
SP - 334
EP - 344
JO - Seminars in nephrology
JF - Seminars in nephrology
IS - 5
ER -