National lung cancer screening trial American college of radiology imaging network specimen biorepository originating from the contemporary screening for the detection of lung cancer trial (NLST, ACRIN 6654): Design, intent, and availability of specimens for validation of lung cancer biomarkers

Edward F. Patz, Neil E. Caporaso, Steven M. Dubinett, Pierre P. Massion, Fred R. Hirsch, John D. Minna, Constantine Gatsonis, Fenghai Duan, Amanda Adams, Charles Apgar, Rosa M. Medina, Denise R. Aberle

Research output: Contribution to journalEditorial

19 Scopus citations

Abstract

Well annotated longitudinal samples were uniformly collected and stored in a central biorepository in the context of a screening trial, with a primary end point to determine whether screening for lung cancer with low-dose helical CT reduces mortality. The NLST ACRIN specimen bank represents a unique opportunity to complement imaging and validate early detection biomarkers for lung cancer. Biomarkers have the potential to improve diagnostic efficiency, reduce cost, and affect the evaluation and management of these patients. Although imaging has played an important role in diagnosing, staging, and following patients with lung cancer, new strategies using biomarkers offer alternative opportunities to address unresolved diagnostic issues in oncology.

Original languageEnglish (US)
Pages (from-to)1502-1506
Number of pages5
JournalJournal of Thoracic Oncology
Volume5
Issue number10
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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