Natriuretic peptides and cardiometabolic health

Deepak K. Gupta, Thomas J. Wang

Research output: Contribution to journalArticle

Abstract

Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertension, cardiac hypertrophy, obesity, diabetes mellitus, the metabolic syndrome, and heart failure. Clinically, natriuretic peptides are robust diagnostic and prognostic markers, and augmenting natriuretic peptides is a target for therapeutic strategies in cardiometabolic disease. This review will summarize current understanding and highlight novel aspects of natriuretic peptide biology.

Original languageEnglish (US)
Pages (from-to)1648-1655
Number of pages8
JournalCirculation Journal
Volume79
Issue number8
DOIs
StatePublished - Jul 24 2015

Keywords

  • Cardiometabolic disease
  • Genetics
  • Guanylyl cyclase
  • Natriuretic peptides
  • Neprilysin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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