TY - JOUR
T1 - Natural compounds in the chemoprevention of alcoholic liver disease
AU - Tu, Yingfeng
AU - Zhu, Shu
AU - Wang, Jing
AU - Burstein, Ezra
AU - Jia, Da
N1 - Funding Information:
We thank all members of our laboratories. This research is supported by National Natural Science Foundation of China (NSFC) grants (#91854121, #31871429, #31671477) and Sichuan Science and Technology Program (2018RZ0128).
Publisher Copyright:
© 2019 John Wiley & Sons, Ltd.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Alcoholic liver disease (ALD), caused by excessive consumption of alcohol, is a major cause of chronic liver disease worldwide. Much effort has been expended to explore the pathogenesis of ALD. Hepatic cell injury, oxidative stress, inflammation, regeneration, and bacterial translocation are all involved in the pathogenesis of ALD. Immediate abstinence is the most important therapeutic treatment for affected individuals. However, the medical treatment for ALD had not advanced in a long period. Intriguingly, an increasing body of research indicates the potential of natural compounds in the targeted therapy of ALD. A plethora of dietary natural products such as flavonoids, resveratrol, saponins, and β-carotene are found to exert protective effects on ALD. This occurs through various mechanisms composed of antioxidative, anti-inflammatory, iron chelation, pro-apoptosis, and/or antiproliferation of hepatic stellate cells and hepatocellular carcinoma cells. In this review, we will summarize current knowledge about the pathogenesis and treatments of ALD and focus on the potential of natural compounds in ALD therapies and underlying mechanisms.
AB - Alcoholic liver disease (ALD), caused by excessive consumption of alcohol, is a major cause of chronic liver disease worldwide. Much effort has been expended to explore the pathogenesis of ALD. Hepatic cell injury, oxidative stress, inflammation, regeneration, and bacterial translocation are all involved in the pathogenesis of ALD. Immediate abstinence is the most important therapeutic treatment for affected individuals. However, the medical treatment for ALD had not advanced in a long period. Intriguingly, an increasing body of research indicates the potential of natural compounds in the targeted therapy of ALD. A plethora of dietary natural products such as flavonoids, resveratrol, saponins, and β-carotene are found to exert protective effects on ALD. This occurs through various mechanisms composed of antioxidative, anti-inflammatory, iron chelation, pro-apoptosis, and/or antiproliferation of hepatic stellate cells and hepatocellular carcinoma cells. In this review, we will summarize current knowledge about the pathogenesis and treatments of ALD and focus on the potential of natural compounds in ALD therapies and underlying mechanisms.
KW - alcoholic liver disease
KW - flavonoids
KW - resveratrol
KW - saponins
KW - β-carotene
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U2 - 10.1002/ptr.6410
DO - 10.1002/ptr.6410
M3 - Review article
C2 - 31264302
AN - SCOPUS:85068528222
SN - 0951-418X
VL - 33
SP - 2192
EP - 2212
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 9
ER -