Natural history of bronchial preinvasive lesions

Taichiro Ishizumi, Annette McWilliams, Calum MacAulay, Adi Gazdar, Stephen Lam

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Preinvasive bronchial lesions defined as dysplasia and carcinoma in situ (CIS) have been considered as precursors of squamous cell carcinoma of the lung. The risk and rate of progression of preinvasive lesions to invasive squamous cell carcinoma as well as the mechanism of progression or regression are incompletely understood. While the evidence for the multistage, stepwise progression model is weak with relatively few documented lesions that progress through various grades of dysplasia to CIS and then to invasive carcinoma, the concept of field carcinogenesis is strongly supported. The presence of high-grade dysplasia or CIS is a risk marker for lung cancer both in the central airways and peripheral lung. Genetic alterations such as loss of heterozygosity in chromosome 3p or chromosomal aneusomy as well as host factors such as the inflammatory load and levels of anti-inflammatory proteins in the lung influence the progression or regression of preinvasive lesions. CIS is different than severe dysplasia at the molecular level and has different clinical outcome. Molecular analysis of dysplastic lesions that progress to CIS or invasive cancer and rare lesions that progress rapidly from hyperplasia or metaplasia to CIS or invasive cancer will shed light on the key molecular determinants driving development to an invasive phenotype versus those associated with tobacco smoke damage.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalCancer and Metastasis Reviews
Volume29
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

Carcinoma in Situ
Natural History
Lung
Squamous Cell Carcinoma
Loss of Heterozygosity
Metaplasia
Smoke
Tobacco
Hyperplasia
Lung Neoplasms
Neoplasms
Carcinogenesis
Anti-Inflammatory Agents
Chromosomes
Carcinoma
Phenotype
Proteins

Keywords

  • Lung cancer
  • Natural history
  • Preinvasive lesions

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ishizumi, T., McWilliams, A., MacAulay, C., Gazdar, A., & Lam, S. (2010). Natural history of bronchial preinvasive lesions. Cancer and Metastasis Reviews, 29(1), 5-14. https://doi.org/10.1007/s10555-010-9214-7

Natural history of bronchial preinvasive lesions. / Ishizumi, Taichiro; McWilliams, Annette; MacAulay, Calum; Gazdar, Adi; Lam, Stephen.

In: Cancer and Metastasis Reviews, Vol. 29, No. 1, 03.2010, p. 5-14.

Research output: Contribution to journalArticle

Ishizumi, T, McWilliams, A, MacAulay, C, Gazdar, A & Lam, S 2010, 'Natural history of bronchial preinvasive lesions', Cancer and Metastasis Reviews, vol. 29, no. 1, pp. 5-14. https://doi.org/10.1007/s10555-010-9214-7
Ishizumi T, McWilliams A, MacAulay C, Gazdar A, Lam S. Natural history of bronchial preinvasive lesions. Cancer and Metastasis Reviews. 2010 Mar;29(1):5-14. https://doi.org/10.1007/s10555-010-9214-7
Ishizumi, Taichiro ; McWilliams, Annette ; MacAulay, Calum ; Gazdar, Adi ; Lam, Stephen. / Natural history of bronchial preinvasive lesions. In: Cancer and Metastasis Reviews. 2010 ; Vol. 29, No. 1. pp. 5-14.
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