TY - JOUR
T1 - Natural history of headache five years after traumatic brain injury
AU - Stacey, Arthur
AU - Lucas, Sylvia
AU - Dikmen, Sureyya
AU - Temkin, Nancy
AU - Bell, Kathleen R.
AU - Brown, Allen
AU - Brunner, Robert
AU - Diaz-Arrastia, Ramon
AU - Watanabe, Thomas K.
AU - Weintraub, Alan
AU - Hoffman, Jeanne M.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - Headache is one of the most frequently reported symptoms following traumatic brain injury (TBI). Little is known about how these headaches change over time. We describe the natural history of headache in individuals with moderate to severe TBI over 5 years after injury. A total of 316 patients were prospectively enrolled and followed at 3, 6, 12, and 60 months after injury. Individuals were 72% male, 73% white, and 55% injured in motor vehicle crashes, with an average age of 42. Pre-injury headache was reported in 17% of individuals. New or worse headache prevalence remained consistent with at least 33% at all time points. Incidence was >17% at all time points with first report of new or worse headache in 20% of participants at 60 months. Disability related to headache was high, with average headache pain (on 0-10 scale) ranging from 5.5 at baseline to 5.7 at 60 months post-injury, and reports of substantial impact on daily life across all time points. More than half of classifiable headaches matched the profile of migraine or probable migraine. Headache is a substantial problem after TBI. Results suggest that ongoing assessment and treatment of headache after TBI is needed, as this symptom may be a problem up to 5 years post-injury.
AB - Headache is one of the most frequently reported symptoms following traumatic brain injury (TBI). Little is known about how these headaches change over time. We describe the natural history of headache in individuals with moderate to severe TBI over 5 years after injury. A total of 316 patients were prospectively enrolled and followed at 3, 6, 12, and 60 months after injury. Individuals were 72% male, 73% white, and 55% injured in motor vehicle crashes, with an average age of 42. Pre-injury headache was reported in 17% of individuals. New or worse headache prevalence remained consistent with at least 33% at all time points. Incidence was >17% at all time points with first report of new or worse headache in 20% of participants at 60 months. Disability related to headache was high, with average headache pain (on 0-10 scale) ranging from 5.5 at baseline to 5.7 at 60 months post-injury, and reports of substantial impact on daily life across all time points. More than half of classifiable headaches matched the profile of migraine or probable migraine. Headache is a substantial problem after TBI. Results suggest that ongoing assessment and treatment of headache after TBI is needed, as this symptom may be a problem up to 5 years post-injury.
KW - TBI
KW - headache
KW - post-traumatic headache
KW - secondary headache
UR - http://www.scopus.com/inward/record.url?scp=85018477040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85018477040&partnerID=8YFLogxK
U2 - 10.1089/neu.2016.4721
DO - 10.1089/neu.2016.4721
M3 - Article
C2 - 27927072
AN - SCOPUS:85018477040
VL - 34
SP - 1558
EP - 1564
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
SN - 0897-7151
IS - 8
ER -