TY - JOUR
T1 - Natural killer cell differentiation
T2 - Insights from knockout and transgenic mouse models and in vitro systems
AU - Williams, Noelle Sevilir
AU - Klem, Jennifer
AU - Puzanov, Igor J.
AU - Sivakumar, P. V.
AU - Schatzle, John D.
AU - Bennett, Michael
AU - Kumar, Vinay
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1998/10
Y1 - 1998/10
N2 - In the last few years, the routine development of knockout and transgenic mice and the ease with which rare progenitor population scan be isolated from hematopoietic organs and cultured in vitro has facilitated significant advances in understanding the lineage and development of natural killer (NK) cells. Fluorescence activated cell sorter analyses have identified a common lymphoid progenitor capable of giving rise to NK, T, and B cells, confirming the lymphoid origin of NK cells. Knockout and transgenic mouse models have pointed to an absolutely critical role for signals sent through the interleukin (IL)-2/15 receptor β (CD122) chain and common γ (γc) chain for NK development. Such signals are likely relayed inside the cell by the tyrosine kinase Jak3, which associates with γc. Recently developed IL-15 and IL-15 receptor α knockout mice have pinpointed IL-15 as the mediator of this signal. Other mouse models have indicated an unexpected role for flt3 ligand in early NK-cell development as well as minor roles for stem cell factor and IL-7 in expanding NK-cell progenitor numbers. Finally, in vitro culture systems have proven useful in identifying the point in NK development at which each of these signals is critical.
AB - In the last few years, the routine development of knockout and transgenic mice and the ease with which rare progenitor population scan be isolated from hematopoietic organs and cultured in vitro has facilitated significant advances in understanding the lineage and development of natural killer (NK) cells. Fluorescence activated cell sorter analyses have identified a common lymphoid progenitor capable of giving rise to NK, T, and B cells, confirming the lymphoid origin of NK cells. Knockout and transgenic mouse models have pointed to an absolutely critical role for signals sent through the interleukin (IL)-2/15 receptor β (CD122) chain and common γ (γc) chain for NK development. Such signals are likely relayed inside the cell by the tyrosine kinase Jak3, which associates with γc. Recently developed IL-15 and IL-15 receptor α knockout mice have pinpointed IL-15 as the mediator of this signal. Other mouse models have indicated an unexpected role for flt3 ligand in early NK-cell development as well as minor roles for stem cell factor and IL-7 in expanding NK-cell progenitor numbers. Finally, in vitro culture systems have proven useful in identifying the point in NK development at which each of these signals is critical.
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U2 - 10.1111/j.1600-065X.1998.tb01229.x
DO - 10.1111/j.1600-065X.1998.tb01229.x
M3 - Review article
C2 - 9850851
AN - SCOPUS:0031725321
SN - 0105-2896
VL - 165
SP - 47
EP - 61
JO - Immunological Reviews
JF - Immunological Reviews
ER -