Natural Osmolyte Trimethylamine N-Oxide Corrects Assembly Defects of Mutant Branched-chain α-Ketoacid Decarboxylase in Maple Syrup Urine Disease

Medicine & Life Sciences

• Maple Syrup Urine Disease 100%
• trimethyloxamine 96%
• Carboxy-Lyases 86%
• 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) 76%
• Thiamine Pyrophosphate 24%
• Chaperonins 23%
• Dissociative Disorders 20%
• Ketosis 20%
• Mutation 17%
• Missense Mutation 16%
• Intellectual Disability 15%
• Adenosine Triphosphate 12%
• Phenotype 9%
• In Vitro Techniques 6%

Chemical Compounds

• Osmolyte 90%
• Mutation 54%
• Heterodimer 48%
• Thiamine 26%
• Trimethylamine 25%
• Cofactor 19%
• Dissociation 15%