Natural resistance to Mycoplasma pulmonis infection in mice: Host resistance gene(s) map to chromosome 4

Wayne C. Lai, Steven P. Pakes, Michael Bennett

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Strains of mice differ greatly in resistance to infection in their lungs with virulent Mycoplasma pulmonis (MP) organisms even during the first 5 days, prior to detection of humoral or T cell mediated acquired immune responses. C57BL/6 mice are resistant, and BALB/c and C3H mice are susceptible, and one major gene, MP, not linked to the H2 major histocompatibility complex, regulates resistance. C57BL/6 x C3H (B x H) and BALB/c x C57BL/6 (C x B) recombinant inbred strain mice were infected intratracheally with the T2 strain of MP. Five days later, the recovery of organisms from tracheolung lavages and lung tissue was determined. The strain distribution pattern of resistance indicated that the MP gene maps to chromosome 4.B6.C-H18 (B6 mice congenic for the BALB/c H18 gene of chromosome 4) were much more susceptible than B6 mice, but were less susceptible than BALB/c mice, supporting the data obtained with the recombinant inbred strain mice, but suggesting that other genes may also influence resistance to infection with MP.

Original languageEnglish (US)
Pages (from-to)241-248
Number of pages8
JournalNatural Immunity
Volume15
Issue number5
StatePublished - Oct 1 1997

Keywords

  • Congenic inbred mice
  • Mycoplasma pulmonis
  • Natural resistance, Mycoplasma pulmonis
  • Pneumonia
  • Recombinant inbred mice

ASJC Scopus subject areas

  • Immunology

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