Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura

Tran Nguyen, Saikripa M. Radhakrishnan, Srinidhi J. Radhakrishnan, David H. Johnson

Research output: Contribution to journalArticlepeer-review

Abstract

Ocular manifestations of thrombotic thrombocytopenic purpura (TTP) are uncommon, and bilateral retinal detachment is a rare presentation of TTP. We report a rare case of bilateral retinal detachment from underlying TTP in a patient presenting with vision loss. A 56-year-old man presented with a 4-day history of bilateral vision loss. Bilateral serous retinal detachment was confirmed using dilated ophthalmoscope examination. Laboratory results were significant for severe thrombocytopenia, peripheral smear revealed numerous schistocytes and ADAMTS13 activity of less than 1%. The patient was treated with plasma exchange (PLEX), prednisone, rituximab and caplacizumab. This case report highlights that prompt treatment of TTP with PLEX, prednisone, rituximab and caplacizumab could result in significant vision recovery.

Original languageEnglish (US)
Article numbere244030
JournalBMJ Case Reports
Volume15
Issue number2
DOIs
StatePublished - Feb 7 2022

Keywords

  • haematology (incl blood transfusion)
  • retina

ASJC Scopus subject areas

  • General Medicine

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