Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

Chen Zhou, Guiyang Hao, Patrick Thomas, Jinbin Liu, Mengxiao Yu, Shasha Sun, Orhan K. Öz, Xiankai Sun, Jie Zheng

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

Original languageEnglish (US)
Pages (from-to)10118-10122
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number40
DOIs
StatePublished - Oct 1 2012

Fingerprint

Pharmacokinetics
Gold
Single photon emission computed tomography
Nanoprobes
Nanoparticles
Infrared radiation
Contrast Media
Glutathione
Fluorescence
Imaging techniques
Molecules

Keywords

  • gold
  • imaging agents
  • luminescence
  • nanoparticles
  • pharmacokinetics

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. / Zhou, Chen; Hao, Guiyang; Thomas, Patrick; Liu, Jinbin; Yu, Mengxiao; Sun, Shasha; Öz, Orhan K.; Sun, Xiankai; Zheng, Jie.

In: Angewandte Chemie - International Edition, Vol. 51, No. 40, 01.10.2012, p. 10118-10122.

Research output: Contribution to journalArticle

Zhou, Chen ; Hao, Guiyang ; Thomas, Patrick ; Liu, Jinbin ; Yu, Mengxiao ; Sun, Shasha ; Öz, Orhan K. ; Sun, Xiankai ; Zheng, Jie. / Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics. In: Angewandte Chemie - International Edition. 2012 ; Vol. 51, No. 40. pp. 10118-10122.
@article{9a4b93ae90d44f4681c61f0a79cec87a,
title = "Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics",
abstract = "A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).",
keywords = "gold, imaging agents, luminescence, nanoparticles, pharmacokinetics",
author = "Chen Zhou and Guiyang Hao and Patrick Thomas and Jinbin Liu and Mengxiao Yu and Shasha Sun and {\"O}z, {Orhan K.} and Xiankai Sun and Jie Zheng",
year = "2012",
month = "10",
day = "1",
doi = "10.1002/anie.201203031",
language = "English (US)",
volume = "51",
pages = "10118--10122",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "40",

}

TY - JOUR

T1 - Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

AU - Zhou, Chen

AU - Hao, Guiyang

AU - Thomas, Patrick

AU - Liu, Jinbin

AU - Yu, Mengxiao

AU - Sun, Shasha

AU - Öz, Orhan K.

AU - Sun, Xiankai

AU - Zheng, Jie

PY - 2012/10/1

Y1 - 2012/10/1

N2 - A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

AB - A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

KW - gold

KW - imaging agents

KW - luminescence

KW - nanoparticles

KW - pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=84867002388&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867002388&partnerID=8YFLogxK

U2 - 10.1002/anie.201203031

DO - 10.1002/anie.201203031

M3 - Article

C2 - 22961978

AN - SCOPUS:84867002388

VL - 51

SP - 10118

EP - 10122

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 40

ER -