Near-infrared emitting radioactive gold nanoparticles with molecular pharmacokinetics

Chen Zhou, Guiyang Hao, Patrick Thomas, Jinbin Liu, Mengxiao Yu, Shasha Sun, Orhan K. Öz, Xiankai Sun, Jie Zheng

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

A molecular nanoprobe: Glutathione-coated near-infrared-emitting radioactive gold nanoparticles have been synthezised and behave like small-molecule contrast agents in pharmocokinetics. These nanoparticles show a rapid distribution half-life, a desirable elimination half-life, and hold promise for single-photon emission computed tomography (SPECT) and fluorescence imaging (see picture).

Original languageEnglish (US)
Pages (from-to)10118-10122
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number40
DOIs
StatePublished - Oct 1 2012

Keywords

  • gold
  • imaging agents
  • luminescence
  • nanoparticles
  • pharmacokinetics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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