Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema

Erik A. Maus, I. Chih Tan, John C. Rasmussen, Milton V. Marshall, Caroline E. Fife, Latisha A. Smith, Renie Guilliod, Eva M. Sevick-Muraca

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background Lymphedema is a complication that may occur after surgical resection and radiation treatment in a number of cancer types and is especially debilitating in regions where treatment options are limited. Although upper and lower extremity lymphedema may be effectively treated with manual lymphatic drainage (MLD) therapies and devices that use compression to direct proximal flow of lymph fluids, head and neck lymphedema is more challenging. Methods and Results Herein, we describe the compassionate use of an investigatory technique of near-infrared (NIR) fluorescence imaging to understand the lymphatic anatomy and function, help direct MLD, and use 3-dimensional (3D) surface profilometry to monitor response to therapy in a patient with head and neck lymphedema after surgery and radiation treatment. Conclusion NIR fluorescence imaging provides a mapping of functional lymph vessels for direction of efficient MLD therapy in the head and neck. Additional studies are needed to assess the efficacy of MLD therapy when directed by NIR fluorescence imaging.

Original languageEnglish (US)
Pages (from-to)448-453
Number of pages6
JournalHead and Neck
Volume34
Issue number3
DOIs
StatePublished - Mar 1 2012

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Lymphedema
Optical Imaging
Neck
Head
Drainage
Lymph
Therapeutics
Compassionate Use Trials
Radiation
Lower Extremity
Anatomy
Equipment and Supplies
Neoplasms

Keywords

  • fluorescence imaging
  • lymphedema
  • manual lymph drainage

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Maus, E. A., Tan, I. C., Rasmussen, J. C., Marshall, M. V., Fife, C. E., Smith, L. A., ... Sevick-Muraca, E. M. (2012). Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema. Head and Neck, 34(3), 448-453. https://doi.org/10.1002/hed.21538

Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema. / Maus, Erik A.; Tan, I. Chih; Rasmussen, John C.; Marshall, Milton V.; Fife, Caroline E.; Smith, Latisha A.; Guilliod, Renie; Sevick-Muraca, Eva M.

In: Head and Neck, Vol. 34, No. 3, 01.03.2012, p. 448-453.

Research output: Contribution to journalArticle

Maus, EA, Tan, IC, Rasmussen, JC, Marshall, MV, Fife, CE, Smith, LA, Guilliod, R & Sevick-Muraca, EM 2012, 'Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema', Head and Neck, vol. 34, no. 3, pp. 448-453. https://doi.org/10.1002/hed.21538
Maus EA, Tan IC, Rasmussen JC, Marshall MV, Fife CE, Smith LA et al. Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema. Head and Neck. 2012 Mar 1;34(3):448-453. https://doi.org/10.1002/hed.21538
Maus, Erik A. ; Tan, I. Chih ; Rasmussen, John C. ; Marshall, Milton V. ; Fife, Caroline E. ; Smith, Latisha A. ; Guilliod, Renie ; Sevick-Muraca, Eva M. / Near-infrared fluorescence imaging of lymphatics in head and neck lymphedema. In: Head and Neck. 2012 ; Vol. 34, No. 3. pp. 448-453.
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