@inproceedings{90671485e0014915948f703ddc907255,
title = "Near-infrared light-triggered dissociation of block copolymer micelles for controlled drug release",
abstract = "In this manuscript, a new near-infrared (NIR) light-breakable amphiphilic block copolymer containing light-sensitive triggering group on the hydrophobic block was developed. By encapsulating NIR dye cypate inside micelles of poly (N-succinyl-N′-4- (2-nitrobenzyloxy)-succinyl chitosan) and exposing the micellar solution to 765.9 nm light, the photo-cleavage reaction was activated and leading to the dissociation of micelles and release of co-loaded hydrophobic species. The UV-vis absorption spectra, fourier transform infrared (FTIR) spectra and 1H nuclear magnetic resonance (1H NMR) spectra of micelles were characterized. Triggered burst release of the payload upon NIR irradiation and subsequent degradation of the micelles were observed by transmission electron microscopy (TEM). This system represents a general and efficient method to circumvent the need for UV or visible light excitation that is a common drawback for light-responsive polymeric systems developed for potential biomedical applications.",
keywords = "NIR light, controlled release, drug delivery, micelles",
author = "Jie Cao and Shanshan Huang and Yuqi Chen and Siwen Li and Samuel Achilefu and Zhiyu Qian and Yueqing Gu",
year = "2013",
doi = "10.1117/12.2003247",
language = "English (US)",
isbn = "9780819493651",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V",
note = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V ; Conference date: 04-02-2013 Through 06-02-2013",
}