Neoadjuvant therapy for localized and locally advanced renal cell carcinoma

Ahmet Bindayi, Zachary A. Hamilton, Michelle L. McDonald, Kendrick Yim, Frederick Millard, Rana R. McKay, Steven C. Campbell, Brian I. Rini, Ithaar H. Derweesh

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Neoadjuvant Targeted Molecular Therapy in the setting of localized and locally advanced renal cell carcinoma has emerged as a strategy to render primary renal tumors amenable to planned surgical resection in settings where radical resection or nephron-sparing surgery was not thought to be safe or feasible. Presurgical tumor reduction has been demonstrated in a number of studies including a recently published randomized double-blind placebo-controlled study, and an expanding body of literature suggests benefit in select patients. Nonetheless, most reports are small phase II clinical trials or retrospective reports. Thus, large randomized clinical trial data are not present to support this approach, and guidelines for use of presurgical therapy have not been promulgated. The advent of immunomodulation through checkpoint inhibition represents an exciting horizon for neoadjuvant strategies. This article reviews the current status and future prospects of neoadjuvant therapy in nonmetastatic renal cell carcinoma.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalUrologic Oncology: Seminars and Original Investigations
Volume36
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Keywords

  • Carcinoma, Renal cell
  • Checkpoint inhibitor
  • Partial nephrectomy
  • Radical nephrectomy
  • Targeted therapy, Molecular

ASJC Scopus subject areas

  • Oncology
  • Urology

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