Neonatal adenoviral infection: A seventeen year experience and review of the literature

Andrea Ronchi, Christopher Doern, Evangeline Brock, Lorenza Pugni, Pablo J. Sánchez

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Objectives To describe the clinical manifestations and short-term outcomes of adenoviral infections in neonates and review all published cases to better determine impact and treatment outcomes. Study design Retrospective cohort study of all neonates hospitalized at Children's Medical Center (CMC) and Parkland Memorial Hospital (PMH), Dallas, TX with laboratory-confirmed adenoviral infection from January 1,1995-December 31, 2012. Neonates were identified by review of the CMC Virology Laboratory's prospective database of all positive adenovirus tests performed in the inpatient and ambulatory settings, and at PMH, of a prospective neonatal database that included all neonatal intensive care unit admissions. Patients also were identified by discharge International Classification of Disease, 9th edition codes for adenoviral infection. The medical records were reviewed, and a review of the English literature was performed. Results During 17 years, 26 neonates had adenoviral infection (25, CMC; 1, PMH). The principle reasons for hospitalization were respiratory signs (88%) and temperature instability (65%). Five (19%) had disseminated disease and 4 (80%) of these infants died. Ribavirin or cidofovir treatment, as well as immune globulin intravenous, did not improve outcomes except in 1 neonate. Literature review (n = 72) combined with our data found that disseminated infection was associated with death (68% vs 21% with localized infection, P <.001). In addition, neonates <14 days of age were more likely to have disseminated disease (44% vs 12%, P =.004) and death (48% vs 8%; P <.001). Conclusion Adenoviral infection in hospitalized neonates was associated with severe morbidity and mortality, especially when infection was disseminated and involved the respiratory tract. Development of new therapeutic strategies is needed.

Original languageEnglish (US)
Pages (from-to)529-535.e4
JournalJournal of Pediatrics
Volume164
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Neonatal adenoviral infection: A seventeen year experience and review of the literature'. Together they form a unique fingerprint.

  • Cite this