TY - JOUR
T1 - Neonatal Leukemoid Reaction
T2 - An Isolated Manifestation of Mosaic Trisomy 21
AU - Weinberg, A. G.
AU - Schiller, G.
AU - Windmiller, J.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1982/4
Y1 - 1982/4
N2 - A phenotypically normal neonate with an unexplained leukemoid reaction had a 46,XX/47,XX, +21 karyotype limited to the hemopoietic system. Although a self-limited myeloproliferative syndrome occurs in Down’s syndrome, this case confirms that an identical disorder may develop in patients with mosaic trisomy 21 and no phenotypic stigmas of Down’s syndrome. Chromosome analysis is a necessary adjunct to the examination of any neonate with an unexplained leukemoid reaction. The presence of trisomy 21 should lead to conservative management, unless there is life-threatening progression of the disease.
AB - A phenotypically normal neonate with an unexplained leukemoid reaction had a 46,XX/47,XX, +21 karyotype limited to the hemopoietic system. Although a self-limited myeloproliferative syndrome occurs in Down’s syndrome, this case confirms that an identical disorder may develop in patients with mosaic trisomy 21 and no phenotypic stigmas of Down’s syndrome. Chromosome analysis is a necessary adjunct to the examination of any neonate with an unexplained leukemoid reaction. The presence of trisomy 21 should lead to conservative management, unless there is life-threatening progression of the disease.
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U2 - 10.1001/archpedi.1982.03970400028007
DO - 10.1001/archpedi.1982.03970400028007
M3 - Article
C2 - 6462054
AN - SCOPUS:0020071767
SN - 0002-922X
VL - 136
SP - 310
EP - 311
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 4
ER -