Neonatal meningitis due to Escherichia coli K1

M. P. Glode, A. Sutton, J. B. Robbins, G. H. McCracken, E. C. Gotschlich, B. Kaijser, L. A. Hanson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Human neonates are uniquely susceptible to serious infections due to Escherichia coli. Investigation of the serotypes of E. coli isolated from neonates with meningitis revealed that >80% of the isolates possessed the capsular polysaccharide antigen designated K1. Cultures of stool from healthy infants, children, and adults have shown that K1 organisms are commonly found in individuals of all ages. Studies of mother-infant pairs have demonstrated transmission of K1 strains from mother to infant shortly after birth. In the rare infant who develops meningitis due to E. coli K1, serotype analysis frequently reveals that the same organism was isolated from the infant's cerebrospinal fluid and from the stools of both mother and infant. Preliminary investigations of humoral immunity demonstrated an age-related acquisition of antibodies to the capsular polysaccharide of E. coli K1 in healthy infants and children. An animal model was developed in which feeding of E. coli K1 to infant rats resulted in colonization, bacteremia, and meningitis in the animals.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume136
Issue number2 Suppl.
StatePublished - 1977

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Meningitis
Escherichia coli
Mothers
Newborn Infant
Humoral Immunity
Bacteremia
Polysaccharides
Cerebrospinal Fluid
Animal Models
Parturition
Antigens
Antibodies
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Glode, M. P., Sutton, A., Robbins, J. B., McCracken, G. H., Gotschlich, E. C., Kaijser, B., & Hanson, L. A. (1977). Neonatal meningitis due to Escherichia coli K1. Journal of Infectious Diseases, 136(2 Suppl.).

Neonatal meningitis due to Escherichia coli K1. / Glode, M. P.; Sutton, A.; Robbins, J. B.; McCracken, G. H.; Gotschlich, E. C.; Kaijser, B.; Hanson, L. A.

In: Journal of Infectious Diseases, Vol. 136, No. 2 Suppl., 1977.

Research output: Contribution to journalArticle

Glode, MP, Sutton, A, Robbins, JB, McCracken, GH, Gotschlich, EC, Kaijser, B & Hanson, LA 1977, 'Neonatal meningitis due to Escherichia coli K1', Journal of Infectious Diseases, vol. 136, no. 2 Suppl..
Glode MP, Sutton A, Robbins JB, McCracken GH, Gotschlich EC, Kaijser B et al. Neonatal meningitis due to Escherichia coli K1. Journal of Infectious Diseases. 1977;136(2 Suppl.).
Glode, M. P. ; Sutton, A. ; Robbins, J. B. ; McCracken, G. H. ; Gotschlich, E. C. ; Kaijser, B. ; Hanson, L. A. / Neonatal meningitis due to Escherichia coli K1. In: Journal of Infectious Diseases. 1977 ; Vol. 136, No. 2 Suppl.
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