Abstract
Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.
Original language | English (US) |
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Pages (from-to) | 249-257 |
Number of pages | 9 |
Journal | International Immunology |
Volume | 18 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2006 |
Keywords
- Cytokines
- Memory
- Rodent
- T lymphocytes
- Viral
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology