Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection

Shaza A. Fadel, Lindsay G. Cowell, Shui Cao, Daniel A. Ozaki, Thomas B. Kepler, Douglas A. Steeber, Marcella Sarzotti

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Immunizations early in life, when the host is most susceptible to infection, allow protective immunological memory to develop. Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming. After secondary challenge, virus-specific CD8+ memory cell populations expand twice as much in neonate-primed mice as in adult-primed mice. We found that when equivalent numbers of virus-specific cells were transferred into virus-susceptible mice, protection from disease was similar whether donor, immune mice were primed as neonates or adults, and IL-4 did not alter in vivo virus-specific CD8+ memory cell effector function. Hence, neonate-primed CD8+ cells develop into memory cells that rival adult-primed cells in proliferation and effector function.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalInternational Immunology
Volume18
Issue number2
DOIs
StatePublished - Feb 1 2006

Keywords

  • Cytokines
  • Memory
  • Rodent
  • T lymphocytes
  • Viral

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Neonate-primed CD8<sup>+</sup> memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection'. Together they form a unique fingerprint.

  • Cite this