Nephrogenic Fibrosing Dermopathy: An Unusual Skin Condition Associated with Kidney Disease

Shuta Ishibe, Mark A. Perazella, Robert F. Reilly

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We report the case of a patient who, while on long-term hemodialysis (HD), developed nephrogenic fibrosing dermopathy, a newly described sclerosing skin disorder. This disorder is characterized by thickened, hardened skin with brawny hyperpigmentation and raised plaques. The most common patient complaints are pruritus and dysesthesia. The extremities are predominantly involved with sparing of the torso and face. Dysfunction of internal organs has not been described, distinguishing it from other fibrosing conditions such as scleroderma. The skin biopsy is characterized by haphazardly arranged dermal collagen spindle cells in the reticular dermis. Extensive mucin deposits are interposed between collagen bundles and there are an increased number of fibroblast-type cells. In contrast to scleroderma, inflammatory cells are generally absent. Corticosteroid therapy can be tried, but in our patient was of no benefit.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalSeminars in Dialysis
Volume16
Issue number3
DOIs
Publication statusPublished - May 2003

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ASJC Scopus subject areas

  • Nephrology

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