Nephrotic edema--pathogenesis and treatment.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The cardinal features of the nephrotic syndrome are albuminuria, hypoalbuminemia, and edema. Traditionally, albuminuria was thought to be responsible primarily for the development of hypoalbuminemia. A decreased plasma-albumin concentration accompanied by a decreased plasma-oncotic pressure was thought responsible for the development of edema and secondary salt retention by the kidney. However, new findings have prompted a reevaluation of these relationships. For example, increased renal catabolism and blunted hepatic synthesis appear to play major roles in the development of hypoalbuminemia. Evidence suggests that primary, rather than secondary, salt retention by the kidney and activation of mechanisms that limit fluid movement across the capillary wall participate in the pathogenesis of the nephrotic syndrome and related edema. The treatment of patients with the nephrotic syndrome should limit proteinuria. This can be accomplished by administering angiotensin-converting enzyme inhibitors, lowering the protein content of the diet, and cautiously using non-steroidal antiinflammatory agents.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalAmerican Journal of the Medical Sciences
Volume306
Issue number1
StatePublished - Jul 1993

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Hypoalbuminemia
Nephrotic Syndrome
Edema
Albuminuria
Kidney
Salts
Non-Steroidal Anti-Inflammatory Agents
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Serum Albumin
Therapeutics
Diet
Pressure
Liver
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nephrotic edema--pathogenesis and treatment. / Palmer, B. F.

In: American Journal of the Medical Sciences, Vol. 306, No. 1, 07.1993, p. 53-67.

Research output: Contribution to journalArticle

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